Macromolecular-Suppressed GABA-Edited MR Spectroscopy in the Posterior Cingulate Cortex of Patients With Acute Mild Traumatic Brain Injury.

Autor: Manzhurtsev AV; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation.; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation.; Moscow State University, Moscow, Russian Federation., Yakovlev AN; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation.; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation.; N.N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences, Moscow, Russian Federation., Bulanov PA; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation.; Moscow State University, Moscow, Russian Federation.; Philips Healthcare, Moscow, Russian Federation., Menshchikov PE; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation.; Philips Healthcare, Moscow, Russian Federation., Ublinskiy MV; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation.; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation., Melnikov IA; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation., Akhadov TA; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation.; Moscow State University, Moscow, Russian Federation., Semenova NA; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation.; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation.; Moscow State University, Moscow, Russian Federation.; N.N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences, Moscow, Russian Federation.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2023 May; Vol. 57 (5), pp. 1433-1442. Date of Electronic Publication: 2022 Aug 29.
DOI: 10.1002/jmri.28410
Abstrakt: Background: Mild traumatic brain injury (mTBI) causes a number of molecular and cellular alterations. There is evidence of an imbalance between the main excitatory (glutamate, Glu) and the main inhibitory (gamma-aminobutyric acid [GABA]) neurotransmitters following mTBI. In vivo human GABA-Glu balance studies following mTBI are sparse.
Purpose: To investigate the effect of acute mTBI on the GABA concentration measured in the posterior cingulate cortex (PCC) of pediatric patients by using the macromolecular (MM)-suppressed GABA J-editing technique.
Study Type: Prospective patient and phantom.
Participants: A total of 14 pediatric patients (mean age 16.0 ± 1.7) with acute mTBI (<3 days after trauma; Glasgow Coma Scale 15) and 16 healthy volunteers (mean age 16.9 ± 2.8). Phantom: 524 cm 3 sphere containing 10 mM glycine, 10 mM GABA.
Field Strength/sequence: A 3 T, MEGA-PRESS pulse sequence.
Assessment: GABA spectra were processed in Gannet software. MM-suppressed GABA editing efficiency was derived from the phantom study. Absolute GABA and glutamate + glutamine (Glx) concentrations were quantified using different types of correction and compared between groups. N-acetyl aspartate (NAA) and choline (Cho) levels relative to tCr were also compared.
Statistical Tests: Shapiro-Wilk test, Mann-Whitney U test, Student t-test, Pearson or Spearman correlations. P < 0.01 was considered statistically significant.
Results: The MM-suppressed GABA editing efficiency was 0.63. GABA signal fit error was <16% for all participants. The GABA concentration in the PCC of the mTBI group was significantly different from that in healthy controls: GABA/tCr was higher by 27%, absolute GABA concentration with different types of correction was higher by ≈17%. No significant differences were observed in Glx concentrations (P ≥ 0.32) or in Glx/tCr (P ≥ 0.1), NAA/tCr (P = 0.55), and Cho/tCr levels (P = 0.85).
Data Conclusion: We report an increase in the GABA concentration in the PCC region in acute mTBI pediatric patients. This may suggest activation of GABA synthesis and impairment of the GABAergic system after acute mTBI.
Evidence Level: 3 TECHNICAL EFFICACY: Stage 1.
(© 2022 International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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