Acute pancreatitis in children - morbidity and outcomes at 1 year.

Autor:	Bhanot A; Faculty of Health Sciences, University of Bristol, Bristol, UK., Majbar AA; Department of Paediatrics, Sabratha Teaching Hospital, Sabratha, Libya., Candler T; Paediatric Diabetes and Endocrinology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK toby.candler@gmail.com., Hunt LP; NIHR Bristol Biomedical Research Centre, Nutrition Theme, University of Bristol, Bristol, UK., Cusick E; Paediatric Surgery, University Hospitals Bristol NHS Foundation Trust, Bristol, UK., Johnson PRV; Nuffield Department of Surgery, University of Oxford, OXFORD, UK.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Shield JP; Paediatric Diabetes and Endocrinology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.; NIHR Bristol Biomedical Research Centre, Nutrition Theme, University of Bristol, Bristol, UK.
Jazyk:	angličtina
Zdroj:	BMJ paediatrics open [BMJ Paediatr Open] 2022 Jul; Vol. 6 (1).
DOI:	10.1136/bmjpo-2022-001487
Abstrakt:	Objective: To establish short-term and medium-term complications 1-year postdiagnosis, of acute pancreatitis (AP) in children aged 0-14 years. Design: One-year follow-up of a prospective monthly surveillance of new cases of AP in children under 15 years through the British Paediatric Surveillance Unit (BPSU) from April 2013 to April 2014. Setting: A monthly surveillance of >3700 consultant paediatricians and paediatric surgeons in the UK and Ireland using the BPSU. Patients: Children aged 0-14 years with a new diagnosis of AP. Main Outcome Measures: The outcomes following AP, including the incidence of complications and comorbidity at diagnosis and at 1 year. Results: Of the 94 new confirmed cases of AP identified in the UK during the study period, 90 cases (96%) were included in the 1-year follow-up. 30 patients (32%) developed further episode(s) of AP. Over one-fifth of patients developed one or more major complication. At initial admission, the most common of these was pancreatic necrosis (n=8, 9%), followed by respiratory failure (n=7, 7%). Reported complications by 1 year were pseudocyst formation (n=9, 10%), diabetes requiring insulin therapy (n=4, 4%) and maldigestion (n=1, 1%). At 1-year postdiagnosis, only 59% of children made a full recovery with no acute or chronic complications or recurrent episodes of AP. Two patients died, indicating a case fatality of ~2.0%. Conclusions: AP in childhood is associated with significant short-term and medium-term complications and comorbidities including risk of recurrence in approximately a third of cases. Competing Interests: Competing interests: No, there are no competing interests. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu