Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection.

Autor:	Mukherjee A; From the Indian Council of Medical Research, New Delhi, India., Kumar G; From the Indian Council of Medical Research, New Delhi, India., Turuk A; From the Indian Council of Medical Research, New Delhi, India., Bhalla A; Postgraduate Institute of Medical Education & Research, Chandigarh, India., Bingi TC; Gandhi Medical College, Telangana, India., Bhardwaj P; All Indian Institute of Medical Sciences, Jodhpur, Rajasthan, India., Baruah TD; All Indian Institute of Medical Sciences, Raipur, Chhattisgarh, India., Mukherjee S; College of Medicine, Sagore Dutta Hospital, Kolkata, West Bengal, India., Talukdar A; Medical College, Kolkata, West Bengal, India., Ray Y; Infectious Disease and Beliaghata General Hospital, Kolkata, West Bengal, India., John M; Christian Medical College, Ludhiana, Punjab, India., Khambholja JR; Smt. NHL, Municipal Medical College, Ahmedabad, Gujarat, India., Patel AH; CIMS Hospital, Ahmedabad, Gujarat, India., Bhuniya S; All India Institute of Medical Sciences, Bhubaneswar, Odisha, India., Joshi R; All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India., Menon GR; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India., Sahu D; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India., Rao VV; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India., Bhargava B; From the Indian Council of Medical Research, New Delhi, India., Panda S; From the Indian Council of Medical Research, New Delhi, India.
Jazyk:	angličtina
Zdroj:	QJM : monthly journal of the Association of Physicians [QJM] 2023 Feb 14; Vol. 116 (1), pp. 47-56.
DOI:	10.1093/qjmed/hcac202
Abstrakt:	Objectives: This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). Methods: NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined. Results: Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6-7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4-0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3-0.7)] were protected from in-hospital mortality. Conclusions: WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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