ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer.

Autor: Rocconi RP; University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mobile, USA., Stanbery L; Gradalis, Inc, Carrollton, USA., Tang M; Stat-Beyond Consulting, Irvine, USA., Madeira da Silva L, Walter A; Gradalis, Inc, Carrollton, USA.; Promedica, Toledo, USA., Monk BJ; Arizona Oncology, (US Oncology Network), University of Arizona, Creighton University, Phoenix, USA., Herzog TJ; University of Cincinnati Cancer Center, Cincinnati, USA., Coleman RL; US Oncology Research, The Woodlands, USA., Manning L; Gradalis, Inc, Carrollton, USA., Wallraven G; Gradalis, Inc, Carrollton, USA., Horvath S; Gradalis, Inc, Carrollton, USA., Bognar E; Gradalis, Inc, Carrollton, USA., Senzer N; Gradalis, Inc, Carrollton, USA., Brun S; Gold Mast Consulting, LLC, Chicago, USA., Nemunaitis J; Gradalis, Inc, Carrollton, USA.
Jazyk: angličtina
Zdroj: Communications medicine [Commun Med (Lond)] 2022 Aug 29; Vol. 2, pp. 106. Date of Electronic Publication: 2022 Aug 29 (Print Publication: 2022).
DOI: 10.1038/s43856-022-00163-y
Abstrakt: Background: Broadened use of predictive molecular and phenotypic profiling amongst oncologists has facilitated optimal integration of targeted- and immuno-therapeutics into clinical care. However, the use of predictive immunomarkers in ovarian cancer (OC) has not consistently translated into clinical benefit. Vigil (gemogenovatucel-T) is a novel plasmid engineered autologous tumor cell immunotherapy designed to knock down the tumor suppressor cytokines, TGFβ1 and TGFβ2, augment local immune function via increased GMCSF expression and enhance presentation of clonal neoantigen epitopes. Methods: All patients enrolled in the VITAL trial (NCT02346747) of maintenance Vigil vs. placebo as front-line therapy with homologous recombination proficient (HRP) stage IIIB-IV newly diagnosed ovarian cancer underwent NanoString gene expression analysis. Tissue was obtained from surgically resected ovarian tumor tissue following surgical debulking. A statistical algorithm was used to analyze the NanoString gene expression data.
Results: Using the NanoString Statistical Algorithm (NSA), we identify high expression of ENTPD1/CD39 (which functions as the rate-limiting step in the production of the immune suppressor adenosine from ATP to ADP) as a presumptive predictor of response to Vigil versus placebo regardless of HRP status on the basis of relapse free survival (median not achieved vs 8.1 months, p  = 0.00007) and overall survival (median not achieved vs 41.4 months, p  = 0.013) extension.
Conclusion: NSA should be considered for application to investigational targeted therapies in order to identify populations most likely to benefit from treatment, in preparation for efficacy conclusive trials.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© The Author(s) 2022.)
Databáze: MEDLINE
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