SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals.

Autor: Sano K; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhavsar D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Floda D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Srivastava K; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gleason C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Sep 01; Vol. 13 (1), pp. 5135. Date of Electronic Publication: 2022 Sep 01.
DOI: 10.1038/s41467-022-32389-8
Abstrakt: Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.
(© 2022. The Author(s).)
Databáze: MEDLINE
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