COX2 Effects on endometrial carcinomas progression.

Autor: Lyndin M; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: n.lyndin@med.sumdu.edu.ua., Kravtsova O; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: 20ollga20@gmail.com., Sikora K; Department of Pathology, Sumy State University, Sumy, Ukraine; Sumy Regional Clinical Perinatal Center, Sumy, Ukraine. Electronic address: ekaterynasikora@gmail.com., Lyndina Y; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: yl.lindina@med.sumdu.edu.ua., Kuzenko Y; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: e.kuzenko@med.sumdu.edu.ua., Awuah WA; Sumy State University, Sumy, Ukraine. Electronic address: andyvans36@yahoo.com., Abdul-Rahman T; Sumy State University, Sumy, Ukraine. Electronic address: drakelin24@gmail.com., Hyriavenko N; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: n.gyryavenko@med.sumdu.edu.ua., Sikora V; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: v.sikora@med.sumdu.edu.ua., Romaniuk A; Department of Pathology, Sumy State University, Sumy, Ukraine. Electronic address: pathomorph@gmail.com.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2022 Oct; Vol. 238, pp. 154082. Date of Electronic Publication: 2022 Aug 17.
DOI: 10.1016/j.prp.2022.154082
Abstrakt: Uterine corpus cancer is one of the most prevalent gynecologic malignancies, among which endometrial cancers (EC) represent about 90 %. Despite the proven predictive value of several immunohistochemical markers, there remains a need to identify new indicators of EC progression and exploit them for therapeutic purposes. Potential candidates with diagnostic and therapeutic efficacy include cyclooxygenases (COXs). We studied 50 EC cases: 30 endometrioid (EEC), 10 serous (SEC), 10 clear-cell endometrial carcinomas (CCEC) and 10 cases of normal endometrial tissues. We investigated the expression of COX2, ER, PR, Ki-67, EGFR, p53, Bcl-2, VEGF, MMP1, CD31, and CD163 immunohistochemically. COX2 levels in EC tissue are elevated compared to the normal endometrium and depend on tumour histological features and differentiation. Elevated COX2 leads to increased tumour cell proliferation, apoptosis inhibition, increased VEGF expression, microvessel density, and M2 macrophage infiltration, and inhibition of PR expression. ER, EGFR, and MMP1 levels are unaffected by COX2, whose levels are independent of patient age and FIGO stage.
Competing Interests: Conflict of interest The authors report no conflict of interest. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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