Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.

Autor: Manik MK; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Shi Y; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia., Li S; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Zaydman MA; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63100, USA., Damaraju N; Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63100, USA.; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO 63100, USA., Eastman S; Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Smith TG; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Gu W; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Masic V; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia., Mosaiab T; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia., Weagley JS; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Hancock SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Vasquez E; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia., Hartley-Tassell L; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia., Kargios N; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK., Maruta N; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Lim BYJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Burdett H; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Landsberg MJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Schembri MA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Prokes I; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK., Song L; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK., Grant M; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK., DiAntonio A; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63100, USA.; Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63100, USA., Nanson JD; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia., Guo M; Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Milbrandt J; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63100, USA., Ve T; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia., Kobe B; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.; The University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD 4072, Australia.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2022 Sep 30; Vol. 377 (6614), pp. eadc8969. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1126/science.adc8969
Abstrakt: Cyclic adenosine diphosphate (ADP)-ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD + ) hydrolysis. We show that v-cADPR (2'cADPR) and v2-cADPR (3'cADPR) isomers are cyclized by O-glycosidic bond formation between the ribose moieties in ADPR. Structures of 2'cADPR-producing TIR domains reveal conformational changes that lead to an active assembly that resembles those of Toll-like receptor adaptor TIR domains. Mutagenesis reveals a conserved tryptophan that is essential for cyclization. We show that 3'cADPR is an activator of ThsA effector proteins from the bacterial antiphage defense system termed Thoeris and a suppressor of plant immunity when produced by the effector HopAM1. Collectively, our results reveal the molecular basis of cADPR isomer production and establish 3'cADPR in bacteria as an antiviral and plant immunity-suppressing signaling molecule.
Databáze: MEDLINE
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