The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management.

Autor: Mohd Fuad AS; Cluster of Cancer Research Initiative IIUM (COCRII), International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia.; Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia., Amran NA; Cluster of Cancer Research Initiative IIUM (COCRII), International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia.; Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia.; Jardin Pharma Berhad, Sunway Subang Business Park, Selangor, 40150, Shah Alam, Malaysia., Nasruddin NS; Department of Diagnostic Craniofacial and Bioscience, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia., Burhanudin NA; Department of Oral Maxillofacial Surgery and Oral Diagnosis, Kulliyyah of Dentistry, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia., Dashper S; Melbourne Dental School, The University of Melbourne, Melbourne, Victoria, 3055, Australia., Arzmi MH; Cluster of Cancer Research Initiative IIUM (COCRII), International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia. hafizarzmi@iium.edu.my.; Jardin Pharma Berhad, Sunway Subang Business Park, Selangor, 40150, Shah Alam, Malaysia. hafizarzmi@iium.edu.my.; Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia. hafizarzmi@iium.edu.my.
Jazyk: angličtina
Zdroj: Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2023 Oct; Vol. 15 (5), pp. 1298-1311. Date of Electronic Publication: 2022 Sep 01.
DOI: 10.1007/s12602-022-09985-7
Abstrakt: Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbalance of microbial composition due to oral infection, which has been reported to contribute to oral carcinogenesis. Therefore, in this review, we summarised the role of probiotics, prebiotics, synbiotics, and postbiotics in promoting a balanced oral microbiome, which may prevent oral carcinogenesis due to oral infections. Probiotics have been shown to produce biofilm, which possesses antibacterial activity against oral pathogens. Meanwhile, prebiotics can support growth and increase the benefit of probiotics. In addition, postbiotics possess antibacterial, anticariogenic, and anticancer properties that potentially aid in oral cancer prevention and treatment. The use of probiotics, prebiotics, synbiotics, and postbiotics for oral cancer management is still limited despite their vast potential, thus, discovering their prospects could herald a novel approach to disease prevention and treatment while participating in combating antimicrobial resistance.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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