Advanced clinical parameters: A complementary hydroxyurea adherence evaluation in sickle cell anemia treatment.

Autor: Moreira ID; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil., Lessa CLM; Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil., Rocha GLG; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil.; Clinicas Hospital of Porto Alegre/RS, Porto Alegre/RS, Brazil., Schmitz LD; Undergraduate Program in Pharmacy, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil., Jahnke VS; Vale do Rio dos Sinos University (UNISINOS), Porto Alegre/RS, Brazil., Fogliatto LM; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil.; Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil., Werlang MC; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil., Rotta LN; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre/RS, Brazil.
Jazyk: angličtina
Zdroj: European journal of haematology [Eur J Haematol] 2022 Dec; Vol. 109 (6), pp. 736-748. Date of Electronic Publication: 2022 Sep 13.
DOI: 10.1111/ejh.13860
Abstrakt: Objectives: Given the complex pathology of sickle cell anemia (SCA) and low adherence to hydroxyurea (HU) treatment, there is a need to seek parameters that identify recent changes in patient status. The advanced clinical parameters (ACPs) allow an early analysis of hematopoiesis. We aimed to draw the demographic profile of non-adherent SCA patients and to verify the use of ACPs as a measure of HU treatment adherence.
Method: In a cross-sectional study, we divided 83 SCA subjects treated with HU into Children (<12 years old) and adolescents/adults (≥12 years old). Their hemogram with the ACPs, electronic medical charts and pharmacy claim data were analyzed.
Results: Non-adherent ≥12 years old patients had significantly increased WBC, absolute neutrophil, lymphocyte, monocyte, and basophil counts, RBC, RET, RDW, and PLT, and significantly decreased MCV and MCH. Subjects in the adolescent/adult group with IG† ≥0.035 cells/mm 3 had the RR for non-adherence increased by 4.6 times (p = .014), and the systemic immune inflammation index (SII) of non-adherent patients was also significantly higher (p = .042).
Conclusion: IG† presents clinical utility in early identification of non-adherence to HU, especially when combined with other parameters, suggesting the evaluation of ACPs in laboratory routine, as they can be easily implemented.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje