| Autor: |
Lee SGW; Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea., Ro YS; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea., Jung E; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea., Moon SB; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, School of Medicine Kyungpook National University and Kyungpook National University Hospital, Daegu, Korea., Park GJ; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, Chungbuk National University Hospital, Cheongju, Korea., Yoon H; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea., Park JH; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea., Shin SD; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.; Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea. |
| Abstrakt: |
Serum biomarkers have potential to help predict prognosis of traumatic brain injury (TBI). The objective of this study was to evaluate the association between serum acylcarnitine levels and functional outcomes at 1 month/6 months after injury for TBI patients with intracranial hemorrhage or diffuse axonal injury. This study is a multi-center prospective cohort study in which adult TBI patients with intracranial injury visiting the emergency departments (EDs) from December 2018 to June 2020 were enrolled. Serum acylcarnitine levels at the time of ED arrival were categorized into four groups: low (1.2-5.5 μmol/L), low-normal (5.6-10.0 μmol/L), high-normal (10.1-14.5 μmol/L), and high (1.4.6-56.6 μmol/L). The study outcome was set as poor functional recovery at 1 month/6 months after injury (Glasgow Outcome Scale score, 1-3). Multi-level logistic regression analyses were conducted to estimate association between serum acylcarnitine and functional outcomes. Among total of 549 patients, poor functional recovery at 1 month and 6 months after injury were observed in 29.1% (160/549) and 29.1% (158/543, follow-up loss n = 6). The odds for 1-month poor functional outcome increased in the high-normal and the high groups [adjusted odds ratios, AORs (95% confidence intervals, CIs): 1.56 (1.09-2.23) and 2.47 (1.63-3.75)], compared with the low-normal group) and also as a continuous variable [1.05 (1.03-1.07) for each 1 μmol/L]. Regarding 6-month mortality, the high group had significantly higher odds when compared with the low-normal group [AOR (95% CI): 2.16 (1.37-3.40)]. Higher serum acylcarnitine levels are associated with poor functional outcomes at 1 month/6 months after injury for TBI patients with intracranial injury. |
