The role of somatosensory innervation of adipose tissues.

Autor: Wang Y; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Leung VH; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA., Zhang Y; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Nudell VS; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA., Loud M; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Servin-Vences MR; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Yang D; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA., Wang K; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA., Moya-Garzon MD; Department of Pathology, Stanford School of Medicine, Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Li VL; Department of Pathology, Stanford School of Medicine, Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Long JZ; Department of Pathology, Stanford School of Medicine, Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Patapoutian A; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA. ardem@scripps.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. ardem@scripps.edu., Ye L; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA. liye@scripps.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2022 Sep; Vol. 609 (7927), pp. 569-574. Date of Electronic Publication: 2022 Aug 31.
DOI: 10.1038/s41586-022-05137-7
Abstrakt: Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis. The mainstream view is that circulating hormones secreted by the fat convey the metabolic state to the brain, which integrates peripheral information and regulates adipocyte function through noradrenergic sympathetic output 1 . Moreover, somatosensory neurons of the dorsal root ganglia innervate adipose tissue 2 . However, the lack of genetic tools to selectively target these neurons has limited understanding of their physiological importance. Here we developed viral, genetic and imaging strategies to manipulate sensory nerves in an organ-specific manner in mice. This enabled us to visualize the entire axonal projection of dorsal root ganglia from the soma to subcutaneous adipocytes, establishing the anatomical underpinnings of adipose sensory innervation. Functionally, selective sensory ablation in adipose tissue enhanced the lipogenic and thermogenetic transcriptional programs, resulting in an enlarged fat pad, enrichment of beige adipocytes and elevated body temperature under thermoneutral conditions. The sensory-ablation-induced phenotypes required intact sympathetic function. We postulate that beige-fat-innervating sensory neurons modulate adipocyte function by acting as a brake on the sympathetic system. These results reveal an important role of the innervation by dorsal root ganglia of adipose tissues, and could enable future studies to examine the role of sensory innervation of disparate interoceptive systems.
(© 2022. The Author(s).)
Databáze: MEDLINE
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