Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes.

Autor:	Baratto SSP; School of Dentistry, UniDomBosco University Center, Curitiba, Paraná, Brazil., Meger MN; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil., Camargo V; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil., Nolasco GMC; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil., Mattos NHR; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil., Roskamp L; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil., Stechman-Neto J; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil., Madalena IR; School of Dentistry, University of the Joinville Region, Joinville, Santa Catarina, Brazil.; School of Dentistry, Presidente Tancredo de Almeida Neves University Center, São João del Rei, Minas Gerais, Brazil.; Department of Restorative Dentistry, School of Dentistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil., Küchler EC; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.; Department of Orthodontics, University of Regensburg, Regensburg, Germany., Baratto-Filho F; School of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.; School of Dentistry, University of the Joinville Region, Joinville, Santa Catarina, Brazil.
Jazyk:	angličtina
Zdroj:	Brazilian dental journal [Braz Dent J] 2022 Jul-Aug; Vol. 33 (4), pp. 12-20.
DOI:	10.1590/0103-6440202204963
Abstrakt:	The study aimed to explore the influence of genetic polymorphisms in ANKK1 and DRD2 on the signs and symptoms of temporomandibular disorder (TMD) in construction workers. This cross-sectional study included only male subjects. All construction workers were healthy and over 18 years age. Illiterate workers and functionally illiterate workers were excluded. The diagnosis of TMD was established according to the Research Diagnostic Criteria for TMD (RDC/TMD). Genomic DNA was used to evaluate the genetic polymorphisms ANKK1 (rs1800497) and DRD2 (rs6275; rs6276) using Real-Time PCR. Chi-square or Fisher exact tests were used to evaluate genotypes and allele distribution among the studied phenotypes. The established alpha of this study was 5%. The sample included a total of 115 patients. The age of the patients ranged from 19 to 70 years (mean age 38.2; standard deviation 11.7). Chronic pain (87.7%), disc displacement (38.2%), and joint inflammation (26.9%) were the most frequently observed signs and symptoms. The genetic polymorphism rs6276 in DRD2 was associated with chronic pain (p=0.033). In conclusion, our study suggests that genetic polymorphisms in DRD2 and ANKK1 may influence TMD signs and symptoms in a group of male construction workers.
Databáze:	MEDLINE
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