Seronegative immunity to SARS-CoV-2: a case study.

Autor: Miller KD; Department of Family Medicine, Medical Center Drive, West Virginia University, Box 9152, Morgantown, WV, 26506, USA., Ashcraft AM; Department of Family Medicine, Medical Center Drive, West Virginia University, Box 9152, Morgantown, WV, 26506, USA. amashcraft@hsc.wvu.edu., Pilkerton CS; Department of Family Medicine, Medical Center Drive, West Virginia University, Box 9152, Morgantown, WV, 26506, USA., Shrader CD; Department of Family Medicine, Medical Center Drive, West Virginia University, Box 9152, Morgantown, WV, 26506, USA.
Jazyk: angličtina
Zdroj: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology [Allergy Asthma Clin Immunol] 2022 Aug 30; Vol. 18 (1), pp. 80. Date of Electronic Publication: 2022 Aug 30.
DOI: 10.1186/s13223-022-00715-w
Abstrakt: Background: COVID-19 presents with a variable clinical course from asymptomatic to severe respiratory distress with nearly 25% mortality in mechanically-ventilated patients. As such, there is uncertainty regarding how host factors modulate the disease course.
Case Presentation: This report examines these factors in two geriatric patients with multiple comorbid conditions who were residents of the long-term care facility in West Virginia that was the epicenter of COVID-19 in the state. Each patient had substantial, unprotected exposure to SARS-CoV-2 with subsequent negative PCR and antibody testing.
Conclusions: These cases could represent an important step in understanding host factors that modulate the disease course and susceptibility of patients exposed to SARS-CoV-2, and illustrate the need for further research into host resistance relating to this pandemic.
(© 2022. The Author(s).)
Databáze: MEDLINE
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