Natural Clinoptilolite Nanoparticles Coated with Phosphatidylcholine.

Autor: Pogorelov AG; Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow oblast, Russia. agpogorelov@rambler.ru., Panait AI; Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow oblast, Russia., Gulin AA; Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia., Stankevich AA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow oblast, Russia., Pogorelova VN; Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow oblast, Russia., Ivanitskii GR; Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow oblast, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2022 Aug; Vol. 505 (1), pp. 156-159. Date of Electronic Publication: 2022 Aug 29.
DOI: 10.1134/S160767292204007X
Abstrakt: A nanocarrier was obtained by coating the natural clinoptilolite particle surface with a phosphatidylcholine layer. The shell effective size does not exceed the thickness of the phospholipid molecular layer, which was confirmed by UV spectrometry and molecular mass spectrometry. The hydrodynamic diameter of the formulated nanocarrier, which was determined by dynamic light scattering, is smaller than the clinoptilolite core size. This effect is assumed to be caused by the phospholipid shell, which reduces the aqueous medium friction. The nanosize of the formulated nanocarrier, the natural clinoptilolite core, and the phospholipid shell together allow a combination of fruitful features that can be used for the fabrication of multifunctional platforms for the delivery of biologically active substances, bioimaging, or as a basis for biosensors.
(© 2022. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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