Distribution of M1 and M2 macrophages in cerebral granulomas caused by Encephalitozoon cuniculi.

Autor: Soto-Domínguez A; Cuerpo Académico Consolidado de Morfología e Histología, Mexico., González-Castillo JA; Cuerpo Académico Consolidado de Zoonosis y Enfermedades Emergentes, Mexico., Castillo-Velázquez U; Cuerpo Académico Consolidado de Zoonosis y Enfermedades Emergentes, Mexico., Rodriguez-Tovar LE; Cuerpo Académico Consolidado de Zoonosis y Enfermedades Emergentes, Mexico., Méndez-Zamora G; Cuerpo Académico Consolidado de Producción Agropecuaria, Biotecnología y Productos Agroalimentarios, Mexico., Zamora-Avila DE; Cuerpo Académico Consolidado de Epidemiología Veterinaria, Mexico., Nevárez-Garza AM; Cuerpo Académico Consolidado de Zoonosis y Enfermedades Emergentes, Mexico. Electronic address: alinega@hotmail.com.
Jazyk: angličtina
Zdroj: Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2022 Oct; Vol. 252, pp. 110481. Date of Electronic Publication: 2022 Aug 24.
DOI: 10.1016/j.vetimm.2022.110481
Abstrakt: Encephalitozoon cuniculi spores cause severe granulomatous inflammation in the brain where mononuclear cells and macrophages infiltrate. Here, we orally infected New Zealand white rabbits with 1 × 10 6 E. cuniculi viable spores to study the recruitment and localization of macrophages in brain granulomas. At day 30 post-infection, the positive phenotype markers iNOS (M1) and Arg-1 (M2) were located in the periphery and center of granulomas, respectively. Live intracytoplasmic spores were found only in positive Arg-1 cells. This is the first work to describe the recruitment and distribution of M1 and M2 macrophages in the brain granulomas of rabbits infected with E. cuniculi.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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