Surfaces with instant and persistent antimicrobial efficacy against bacteria and SARS-CoV-2.

Autor:	Dhyani A; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Repetto T; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA., Bartikofsky D; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA., Mirabelli C; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA., Gao Z; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA., Snyder SA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA., Snyder C; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA., Mehta G; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA., Wobus CE; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA., VanEpps JS; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Departments of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109, USA., Tuteja A; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Jazyk:	angličtina
Zdroj:	Matter [Matter] 2022 Nov 02; Vol. 5 (11), pp. 4076-4091. Date of Electronic Publication: 2022 Aug 24.
DOI:	10.1016/j.matt.2022.08.018
Abstrakt:	Surfaces contaminated with bacteria and viruses contribute to the transmission of infectious diseases and pose a significant threat to global public health. Modern day disinfection either relies on fast-acting (>3-log reduction within a few minutes), yet impermanent, liquid-, vapor-, or radiation-based disinfection techniques, or long-lasting, but slower-acting, passive antimicrobial surfaces based on heavy metal surfaces, or metallic nanoparticles. There is currently no surface that provides instant and persistent antimicrobial efficacy against a broad spectrum of bacteria and viruses. In this work, we describe a class of extremely durable antimicrobial surfaces incorporating different plant secondary metabolites that are capable of rapid disinfection (>4-log reduction) of current and emerging pathogens within minutes, while maintaining persistent efficacy over several months and under significant environmental duress. We also show that these surfaces can be readily applied onto a variety of desired substrates or devices via simple application techniques such as spray, flow, or brush coating. Competing Interests: The University of Michigan has applied for a patent based on this technology. A startup company HygraTek LLC has licensed this technology from the University of Michigan. A.T. has equity and has been a paid consultant, for HygraTek LLC. (© 2022 Elsevier Inc.)
Databáze:	MEDLINE
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