Disruptions to routine childhood vaccinations in low- and middle-income countries during the COVID-19 pandemic: A systematic review.

Autor:	Cardoso Pinto AM; School of Medicine, Imperial College London, London, United Kingdom., Ranasinghe L; Academic Foundation Doctor, Imperial College London, London, United Kingdom., Dodd PJ; School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom., Budhathoki SS; Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom., Seddon JA; Department of Infectious Disease, Imperial College London, London, United Kingdom.; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa., Whittaker E; Department of Infectious Disease, Imperial College London, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2022 Aug 11; Vol. 10, pp. 979769. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).
DOI:	10.3389/fped.2022.979769
Abstrakt:	Background: The COVID-19 pandemic has disrupted routine childhood vaccinations worldwide with low- and middle-income countries (LMICs) most affected. This study aims to quantify levels of disruption to routine vaccinations in LMICs. Methods: A systematic review (PROSPERO CRD42021286386) was conducted of MEDLINE, Embase, Global Health, CINAHL, Scopus and MedRxiv, on the 11th of February 2022. Primary research studies published from January 2020 onwards were included if they reported levels of routine pediatrics vaccinations before and after March 2020. Study appraisal was performed using NHLBI tool for cross-sectional studies. Levels of disruption were summarized using medians and interquartile ranges. Results: A total of 39 cross-sectional studies were identified. These showed an overall relative median decline of -10.8% [interquartile range (IQR) -27.6%, -1.4%] across all vaccines. Upper-middle-income countries (upper-MICs) (-14.3%; IQR -24.3%, -2.4%) and lower-MICs (-18.0%; IQR -48.6%, -4.1%) showed greater declines than low-income countries (-3.1%; IQR -12.8%, 2.9%), as did vaccines administered at birth (-11.8%; IQR -27.7%, -3.5%) compared to those given after birth (-8.0%; IQR -28.6%, -0.4%). Declines during the first 3 months of the pandemic (-8.1%; IQR -35.1%, -1.4%) were greater than during the remainder of 2020 (-3.9%; IQR -13.0%, 11.4%) compared to baseline. Conclusion: There has been a decline in routine pediatric vaccination, greatest in MICs and for vaccines administered at birth. Nations must prioritize catch-up programs alongside public health messaging to encourage vaccine uptake. Systematic Review Registration: Identifier: CRD42021286386. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Cardoso Pinto, Ranasinghe, Dodd, Budhathoki, Seddon and Whittaker.)
Databáze:	MEDLINE
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