Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders.

Autor:	Keeratitanont K; Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Theerakulpisut D; Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Auvichayapat N; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Suphakunpinyo C; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Patjanasoontorn N; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Tiamkao S; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Tepmongkol S; Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Chulalongkorn University Biomedical Imaging Group (CUBIG), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Khiewvan B; Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Raruenrom Y; Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Srisuruk P; Department of Educational Psychology and Counseling, Faculty of Education, Khon Kaen University, Khon Kaen, Thailand.; Research and Service Institute for Autism, Khon Kaen University, Khon Kaen, Thailand., Paholpak S; Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Research and Service Institute for Autism, Khon Kaen University, Khon Kaen, Thailand., Auvichayapat P; Noninvasive Brain Stimulation Research Group of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Research and Service Institute for Autism, Khon Kaen University, Khon Kaen, Thailand.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Aug 10; Vol. 15, pp. 901016. Date of Electronic Publication: 2022 Aug 10 (Print Publication: 2022).
DOI:	10.3389/fnmol.2022.901016
Abstrakt:	Background and Rationale: Autism spectrum disorder (ASD) is a neuropsychiatric disorder that has no curative treatment. Little is known about the brain laterality in patients with ASD. F-18 fluorodeoxyglucose positron emission computed tomography (F-18 FDG PET/CT) is a neuroimaging technique that is suitable for ASD owing to its ability to detect whole brain functional abnormalities in a short time and is feasible in ASD patients. The purpose of this study was to evaluate brain laterality using F-18 FDG PET/CT in patients with high-functioning ASD. Materials and Methods: This case-control study recruited eight ASD patients who met the DSM-5 criteria, the recorded data of eight controls matched for age, sex, and handedness were also enrolled. The resting state of brain glucose metabolism in the regions of interest (ROIs) was analyzed using the Q.Brain software. Brain glucose metabolism and laterality index in each ROI of ASD patients were compared with those of the controls. The pattern of brain metabolism was analyzed using visual analysis and is reported in the data description. Results: The ASD group's overall brain glucose metabolism was lower than that of the control group in both the left and right hemispheres, with mean differences of 1.54 and 1.21, respectively. We found statistically lower mean glucose metabolism for ASD patients than controls in the left prefrontal lateral ( Z = 1.96, p = 0.049). The left laterality index was found in nine ROIs for ASD and 11 ROIs for the control. The left laterality index in the ASD group was significantly lower than that in the control group in the prefrontal lateral ( Z = 2.52, p = 0.012), precuneus ( Z = 2.10, p = 0.036), and parietal inferior ( Z = 1.96, p = 0.049) regions. Conclusion: Individuals with ASD have lower brain glucose metabolism than control. In addition, the number of ROIs for left laterality index in the ASD group was lower than control. Left laterality defects may be one of the causes of ASD. This knowledge can be useful in the treatment of ASD by increasing the left-brain metabolism. This trial was registered in the Thai Clinical Trials Registry (TCTR20210705005). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Keeratitanont, Theerakulpisut, Auvichayapat, Suphakunpinyo, Patjanasoontorn, Tiamkao, Tepmongkol, Khiewvan, Raruenrom, Srisuruk, Paholpak and Auvichayapat.)
Databáze:	MEDLINE
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