Impact of Steam Inhalation, Saline Gargling, and Povidone-Iodine Gargling on Clinical Outcome of COVID-19 Patients in Bengaluru, Karnataka: A Randomized Control Trial.

Autor:	Chalageri VH; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Bhushan S; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Saraswathi S; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Ranganath TS; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Rani VD; Department of Health and Family welfare, Bruhat Bengaluru Mahanagara Palike, Bengaluru, Karnataka, India., Majgi SM; Department of Community Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India., Vijay K; Department of Microbiology, Kempegowda Institute of Medical Science, Bengaluru, Karnataka, India., Hema MS; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Sanadi SL; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Nasreen PM; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Shoyaib KM; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Partheeban I; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Vanitha B; Department of Community Medicine, Bowring and Lady Curzon Medical College and Research Institute, Bengaluru, Karnataka, India., Souza ND; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India., Vaddatti JS; Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
Jazyk:	angličtina
Zdroj:	Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine [Indian J Community Med] 2022 Apr-Jun; Vol. 47 (2), pp. 207-212. Date of Electronic Publication: 2022 Jul 11.
DOI:	10.4103/ijcm.ijcm_804_21
Abstrakt:	Context: In the absence of any specific treatment available for COVID-19, people started practicing traditional nonpharmacological preventive home remedies such as salt water gargling and steam inhalation. The available research evidence on some of these measures opines that steam inhalation, saline gargling, and povidone-iodine gargling does have virucidal properties and do provide symptomatic relief. Aims: The aim is to test this hypothesis, and the present trial was undertaken with an objective to assess the effect of steam inhalation, saline gargling, and povidone-iodine gargling among the COVID-19-positive patients with respect to early test negativity and clinical recovery. Methodology: Open-labeled, parallel, randomized controlled trial was conducted among asymptomatic or mild COVID-19-positive patients in Bangalore from September 2020 to February 2021. In each group of steam inhalation, saline gargling, povidone-iodine gargling, and control, twenty participants were allocated. Daily follow-up was done for 21 days to assess early test negativity and clinical recovery. Trial Registry Number: Clinical Trial Registry India/2020/09/027687. Results: Among 80 participants recruited, 65 (81.3%) were symptomatic. Early test negativity was seen in povidone-iodine gargling group of 6 days (KaplanMeier survival curve, BreslowGeneralized Wilcoxon test P = 0.7 as per the intention-to-treat and as per-protocol P = 0.8). Significant clinical recovery was seen in saline gargling group (4 days, P = 0.01). Conclusion: Povidone-iodine gargling was effective in providing early test negativity, whereas saline gargling was effective in early clinical recovery. Competing Interests: There are no conflicts of interest. (Copyright: © 2022 Indian Journal of Community Medicine.)
Databáze:	MEDLINE
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