Spontaneous brain activity, graph metrics, and head motion related to prospective post-traumatic stress disorder trauma-focused therapy response.

Autor:	van Lutterveld R; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, Netherlands.; Department of Psychiatry, University Medical Centre, Utrecht, Netherlands., Varkevisser T; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, Netherlands.; Department of Psychiatry, University Medical Centre, Utrecht, Netherlands., Kouwer K; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, Netherlands.; Department of Psychiatry, University Medical Centre, Utrecht, Netherlands., van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States., Kennis M; ARQ National Psychotrauma Centre, ARQ Centre of Expertise for the Impact of Disasters and Crises, Diemen, Netherlands., Hueting M; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, Netherlands., van Montfort S; Department of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., van Dellen E; Department of Psychiatry, University Medical Centre, Utrecht, Netherlands.; Department of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Geuze E; Brain Research and Innovation Centre, Ministry of Defence, Utrecht, Netherlands.; Department of Psychiatry, University Medical Centre, Utrecht, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2022 Aug 12; Vol. 16, pp. 730745. Date of Electronic Publication: 2022 Aug 12 (Print Publication: 2022).
DOI:	10.3389/fnhum.2022.730745
Abstrakt:	Introduction: Trauma-focused psychotherapy for post-traumatic stress disorder (PTSD) is effective in about half of all patients. Investigating biological systems related to prospective treatment response is important to gain insight in mechanisms predisposing patients for successful intervention. We studied if spontaneous brain activity, brain network characteristics and head motion during the resting state are associated with future treatment success. Methods: Functional magnetic resonance imaging scans were acquired from 46 veterans with PTSD around the start of treatment. Psychotherapy consisted of trauma-focused cognitive behavioral therapy (tf-CBT), eye movement desensitization and reprocessing (EMDR), or a combination thereof. After intervention, 24 patients were classified as treatment responders and 22 as treatment resistant. Differences between groups in spontaneous brain activity were evaluated using amplitude of low-frequency fluctuations (ALFF), while global and regional brain network characteristics were assessed using a minimum spanning tree (MST) approach. In addition, in-scanner head motion was assessed. Results: No differences in spontaneous brain activity and global network characteristics were observed between the responder and non-responder group. The right inferior parietal lobule, right putamen and left superior parietal lobule had a more central position in the network in the responder group compared to the non-responder group, while the right dorsolateral prefrontal cortex (DLPFC), right inferior frontal gyrus and left inferior temporal gyrus had a less central position. In addition, responders showed less head motion. Discussion: These results show that areas involved in executive functioning, attentional and action processes, learning, and visual-object processing, are related to prospective PTSD treatment response in veterans. In addition, these findings suggest that involuntary micromovements may be related to future treatment success. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 van Lutterveld, Varkevisser, Kouwer, van Rooij, Kennis, Hueting, van Montfort, van Dellen and Geuze.)
Databáze:	MEDLINE
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