The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma.

Autor:	Zijtregtop EAM; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands., Tromp I; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands., Dandis R; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Zwaan CM; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands., Lam KH; Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands., Meyer-Wentrup FAG; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Beishuizen A; Department of Hemato-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	Pathology oncology research : POR [Pathol Oncol Res] 2022 Aug 11; Vol. 28, pp. 1610482. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).
DOI:	10.3389/pore.2022.1610482
Abstrakt:	Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Zijtregtop, Tromp, Dandis, Zwaan, Lam, Meyer-Wentrup and Beishuizen.)
Databáze:	MEDLINE
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