New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems.

Autor:	Duchemin N; Queen Mary University of London, Department of Chemistry, Mile End Road, London E1 4NS, United Kingdom.; NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, Berlin 10589, Germany., Aubert S; Queen Mary University of London, Department of Chemistry, Mile End Road, London E1 4NS, United Kingdom., de Souza JV; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle NE1 7RU, United Kingdom., Bethge L; NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, Berlin 10589, Germany., Vonhoff S; NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, Berlin 10589, Germany., Bronowska AK; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle NE1 7RU, United Kingdom., Smietana M; Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 1919 Route de Mende, Montpellier 34095, France., Arseniyadis S; Queen Mary University of London, Department of Chemistry, Mile End Road, London E1 4NS, United Kingdom.
Jazyk:	angličtina
Zdroj:	JACS Au [JACS Au] 2022 Aug 02; Vol. 2 (8), pp. 1910-1917. Date of Electronic Publication: 2022 Aug 02 (Print Publication: 2022).
DOI:	10.1021/jacsau.2c00271
Abstrakt:	By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asymmetric catalysis, many challenges still remain to be faced, in particular when it comes to designing a "universal" catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asymmetric catalysis. Competing Interests: The authors declare no competing financial interest. (© 2022 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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