NMR spectroscopy spotlighting immunogenicity induced by COVID-19 vaccination to mitigate future health concerns.

Autor:	Ali S; Department of Chemistry, Federal University of Paraná, CEP 81530-900, Curitiba, PR, Brazil.; Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, CEP13635-900, Pirassununga, SP, Brazil., Nedvědová Š; Department of Chemistry, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Kamýcká 129, 165 00, Praha-Suchdol, Prague, Czech Republic., Badshah G; Department of Chemistry, Federal University of Paraná, CEP 81530-900, Curitiba, PR, Brazil., Afridi MS; Department of Plant Pathology, Federal University of Lavras, Lavras, Brazil., Abdullah; Department of Health and Biological Sciences, Abasyn University Peshawar, CEP 25000, Peshawar, Pakistan., Dutra LM; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, CEP 56304-205, Petrolina, Brazil., Ali U; Department of Physics and Chemistry, University of Malakand, CEP 18800, Dir (L), Malakand, Pakistan., Faria SG; Department of Chemistry, Federal University of Paraná, CEP 81530-900, Curitiba, PR, Brazil., Soares FLF; Department of Chemistry, Federal University of Paraná, CEP 81530-900, Curitiba, PR, Brazil., Rahman RU; Laboratory of Physiology and Control of Arthropod Vectors, IOC, Fiocruz, CEP 21040-900, RJ, Brazil., Cançado FACQ; Department of Basic Science, Faculty of Animal Science and Food Engineering, University of São Paulo, CEP 13635-900, Pirassununga, SP, Brazil., Aoyanagi MMCC; Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, CEP13635-900, Pirassununga, SP, Brazil., Freire LGD; Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, CEP13635-900, Pirassununga, SP, Brazil., Santos ADC; Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil., Barison A; Department of Chemistry, Federal University of Paraná, CEP 81530-900, Curitiba, PR, Brazil., Oliveira CAF; Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, CEP13635-900, Pirassununga, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Current research in immunology [Curr Res Immunol] 2022; Vol. 3, pp. 199-214. Date of Electronic Publication: 2022 Aug 22.
DOI:	10.1016/j.crimmu.2022.08.006
Abstrakt:	In this review, the disease and immunogenicity affected by COVID-19 vaccination at the metabolic level are described considering the use of nuclear magnetic resonance (NMR) spectroscopy for the analysis of different biological samples. Consistently, we explain how different biomarkers can be examined in the saliva, blood plasma/serum, bronchoalveolar-lavage fluid (BALF), semen, feces, urine, cerebrospinal fluid (CSF) and breast milk. For example, the proposed approach for the given samples can allow one to detect molecular biomarkers that can be relevant to disease and/or vaccine interference in a system metabolome. The analysis of the given biomaterials by NMR often produces complex chemical data which can be elucidated by multivariate statistical tools, such as PCA and PLS-DA/OPLS-DA methods. Moreover, this approach may aid to improve strategies that can be helpful in disease control and treatment management in the future. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
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