HIV stigma limits the effectiveness of PMTCT in Guinea: the ANRS 12344-DIAVINA study.

Autor:	Breton G; Solthis, Paris, France.; Infectious Diseases, CHU Pitié-Salpêtrière, Paris, France., Diallo OH; Solthis, Conakry, Guinea., Cissé M; Donka Hospital, Conakry, Guinea., Diallo OH; Fondation Espoir Guinée, Conakry, Guinea., Diallo NA; Fondation Espoir Guinée, Conakry, Guinea., Soumaoro SA; Maternity, Ignace Deen Hospital, Conakry, Guinea., Camara Y; Pediatry, Ignace Deen Hospital, Conakry, Guinea., Montoyo A; ANRS, Paris, France., Rouzioux C; Virology CHU Necker, Paris Descartes University, Paris, France., Koita Y; PNLSH, Conakry, Guinea., Peytavin G; Pharmacologie-Toxicologie, AP-HP, Hôpital Bichat-Claude Bernard & IAME, UMR 1137, Sorbonne Paris Cité & INSERM, Université Paris Diderot, Paris, France., Tubiana R; Infectious Diseases, CHU Pitié-Salpêtrière, Paris, France., Frange P; Clinical Microbiology, Necker-Enfants malades Hospital, Assistance Publique-Hôpitaux de Paris (APHP), EHU 7327, Institut Imagine, Université de Paris, Paris, France.
Jazyk:	angličtina
Zdroj:	The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2022 Oct 28; Vol. 77 (11), pp. 3093-3101.
DOI:	10.1093/jac/dkac287
Abstrakt:	Background: Nearly half of HIV-infected children worldwide are born in West and Central African countries where access to prevention of mother-to-child transmission of HIV (PMTCT) programmes is still limited. WHO recommends reinforced antiretroviral prophylaxis for infants at high risk of mother-to-child transmission of HIV (MTCT) but its implementation needs further investigation in the field. Methods: The prospective ANRS 12344-DIAVINA study evaluated the feasibility of a strategy combining early infant diagnosis (EID) and reinforced antiretroviral prophylaxis in high-risk infants as identified by interviews with mothers at Ignace Deen Hospital, Conakry, Guinea. Results: 6493 women were admitted for delivery, 6141 (94.6%) accepted HIV testing and 114 (1.9%) were HIV positive. Among these, 51 high-risk women and their 56 infants were included. At birth, a blood sample was collected for infant EID and reinforced antiretroviral prophylaxis was initiated in 48/56 infants (86%, 95% CI 77%-95%). Iron supplementation was given to 35% of infants for non-severe anaemia. Retrospective measurement of maternal plasma viral load (pVL) at delivery revealed that 52% of women had pVL < 400 copies/mL attributable to undisclosed HIV status and/or antiretroviral intake. Undisclosed HIV status was associated with self-stigmatization (85% versus 44%, P = 0.02). Based on the results of maternal pVL at delivery, 'real' high-risk infants were more frequently lost to follow-up (44% versus 8%, P < 0.01) in comparison with low-risk infants, and this was associated with mothers' stigmatization (69% versus 31%, P < 0.01). Conclusions: Reinforced antiretroviral prophylaxis and EID at birth are widely feasible. However, mothers' self-disclosure of HIV status and antiretroviral intake do not allow adequate evaluation of MTCT risk, which argues for maternal pVL measurement near delivery. Furthermore, actions against stigmatization are crucial to improve PMTCT. (© The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.)
Databáze:	MEDLINE
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