| Autor: |
Martakov IS; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Vaseneva IN; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Torlopov MA; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Legki PV; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Paderin NM; Institute of Physiology of Federal Research Centre, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 50, Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Patov SA; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Mikhaylov VI; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation., Sitnikov PA; Institute of Chemistry, Federal Research Centre 'Komi Science Centre, Ural Branch, Russian Academy of Sciences', 48 Pervomayskaya Street, Syktyvkar 167982, Russian Federation. |
| Abstrakt: |
Vitamin D3 deficiency is a major public health problem worldwide, and standard cholecalciferol formulations provide poor absorbability of the vitamin. Several biphasic formulas have been proposed to overcome the disadvantages in which Pickering emulsions stand out in particular. This paper describes olive oil-in-water Pickering emulsions stabilized by pseudoboehmite (AlOOH), cellulose nanocrystals (CNC), and their heterocoagulates. Colloidal properties were assessed by laser Doppler microelectrophoresis, potentiometric titration, and rheology. It was shown that the heterocoagulation of CNC and AlOOH led to a drastic change in surface properties (ζ-potential, p K a , and number of active centers), which promoted the formation of more stable emulsions with the smallest size of droplets and the highest viscosity among the studied samples. Simulated digestion studies showed the targeted release in the small intestine medium where cholecalciferol should be delivered. High-performance liquid chromatography showed the efficient encapsulation of cholecalciferol in emulsions (86% of initial concentration). Oral administration to laboratory mice of initial nanoparticles and emulsions stabilized by them showed nontoxicity for all of the components, and they were estimated to be class V materials. The proposed emulsions have great potential as targeted delivery systems of lipophilic drugs. |
