Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity.

Autor: Arputhasamy C; Buck Institute for Research On Aging, Novato, CA, USA., Foulger AC; Buck Institute for Research On Aging, Novato, CA, USA., Lucanic M; Buck Institute for Research On Aging, Novato, CA, USA., Rane A; Buck Institute for Research On Aging, Novato, CA, USA., Schmidt M; Buck Institute for Research On Aging, Novato, CA, USA.; School of Gerontology, USC Leonard Davis, University of Southern California, Los Angeles, CA, USA., Garrett T; Buck Institute for Research On Aging, Novato, CA, USA., Broussalian M; Buck Institute for Research On Aging, Novato, CA, USA.; Dominican University of California, San Rafael, CA, USA., Battistoni E; Buck Institute for Research On Aging, Novato, CA, USA.; Dominican University of California, San Rafael, CA, USA., Brem RB; Buck Institute for Research On Aging, Novato, CA, USA.; Department of Plant and Microbial Biology, UC Berkeley, Berkeley, CA, USA., Lithgow GJ; Buck Institute for Research On Aging, Novato, CA, USA.; School of Gerontology, USC Leonard Davis, University of Southern California, Los Angeles, CA, USA., Chamoli M; Buck Institute for Research On Aging, Novato, CA, USA. mchamoli@buckinstitute.org., Andersen JK; Buck Institute for Research On Aging, Novato, CA, USA. jandersen@buckinstitute.org.; School of Gerontology, USC Leonard Davis, University of Southern California, Los Angeles, CA, USA. jandersen@buckinstitute.org.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2023 Apr; Vol. 45 (2), pp. 1237-1245. Date of Electronic Publication: 2022 Aug 26.
DOI: 10.1007/s11357-022-00647-8
Abstrakt: Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an FDA approved drug sodium polystyrene sulfonate (SPS), used to reduce high blood potassium in humans, enhances lysosomal function both in C. elegans and in human neuronal cells. Enhanced lysosomal function following SPS treatment is accompanied by the suppression of proteotoxicity caused by expression of the neurotoxic peptides Aβ and TAU. Additionally, treatment with SPS imparts health benefits as it significantly increases lifespan in C. elegans. Overall our work supports the potential use of SPS as a prospective geroprotective intervention.
(© 2022. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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