| Autor: |
Mahmoud AH; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt., Mahmoud BK; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt., Samy MN; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt., Fouad MA; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt., Kamel MS; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt., Matsunami K; Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. |
| Abstrakt: |
One new iridoid named aureanin ( 1 ) was isolated from the leaves of Tabebuia aurea (Silva Manso) Benth. & Hook.f. ex S.Moore, together with eight known compounds, isoquercetin ( 2 ), astragalin ( 3 ), callicoside B ( 4 ), amphipaniculoside E ( 5 ), rehmaglutin D ( 6 ), quercetin-3-sambubioside ( 7 ), rutin ( 8 ), kaempferol-3- O -rutinoside ( 9 ). The structures of the isolated compounds were elucidated and confirmed by spectroscopic methods, including 1 D and 2 D NMR experiments, as well as HR-ESI-MS. Compounds 1-9 were evaluated for their in vitro cytotoxic activity against three human cancer cell lines (A549, HepG2, and MCF-7) and Leishmania major . Compound 4 showed activity against A549 (IC 50 : 36.8 ± 1.5 μg/mL, etoposide (positive control): 28.1 ± 4.2 μg/mL), however, none of the compounds were active against L. major . |
