SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers.

Autor:	Porru S; Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy., Monaco MGL; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy., Spiteri G; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy., Carta A; Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.; Occupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy., Pezzani MD; Infectious Diseases Unit, University Hospital of Verona, 37134 Verona, Italy., Lippi G; Section of Clinical Biochemistry, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy., Gibellini D; Section of Microbiology, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy., Tacconelli E; Infectious Diseases Unit, University Hospital of Verona, 37134 Verona, Italy.; Section of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy., Dalla Vecchia I; Section of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy., Sala E; Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25121 Brescia, Italy., Sansone E; Unit of Occupational Health and Industrial Hygiene, Department of Medical Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy., De Palma G; Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25121 Brescia, Italy.; Unit of Occupational Health and Industrial Hygiene, Department of Medical Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy., Bonfanti C; Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25121 Brescia, Italy., Lombardo M; Chief Executive Office, ASST Spedali Civili di Brescia, 25121 Brescia, Italy., Terlenghi L; Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25121 Brescia, Italy., Pira E; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy., Mansour I; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy., Coggiola M; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy., Ciocan C; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.; Occupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy., Godono A; Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy., Tardon A; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain., Rodriguez-Suarez MM; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain., Fernandez-Tardon G; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain., Jimeno-Demuth FJ; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain., Castro-Delgado RV; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain., Iglesias Cabo T; Health Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain., Scapellato ML; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.; University Hospital of Padova, 35128 Padova, Italy., Liviero F; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.; University Hospital of Padova, 35128 Padova, Italy., Moretto A; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.; University Hospital of Padova, 35128 Padova, Italy., Mason P; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.; University Hospital of Padova, 35128 Padova, Italy., Pavanello S; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.; University Hospital of Padova, 35128 Padova, Italy., Volpin A; University Hospital of Padova, 35128 Padova, Italy., Vimercati L; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy., Tafuri S; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy., De Maria L; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy., Sponselli S; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy., Stefanizzi P; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy., Caputi A; Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy., Gobba F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy., Modenese A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy., Casolari L; Health Surveillance Service, University Hospital of Modena, 41125 Modena, Italy., Garavini D; Health Surveillance Service, University Hospital of Modena, 41125 Modena, Italy., D'Elia C; Health Surveillance Service, University Hospital of Modena, 41125 Modena, Italy., Mariani S; Health Surveillance Service, University Hospital of Modena, 41125 Modena, Italy., Filon FL; Unit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy., Cegolon L; Unit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy., Negro C; Unit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy., Ronchese F; Unit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy., Rui F; Unit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy., De Michieli P; Unit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy., Murgia N; Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy., Dell'Omo M; Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy., Muzi G; Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy., Fiordi T; Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy., Gambelunghe A; Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy., Folletti I; Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy., Mates D; National Institute of Public Health, 050463 Bucharest, Romania., Calota VC; National Institute of Public Health, 050463 Bucharest, Romania., Neamtu A; National Institute of Public Health, 050463 Bucharest, Romania., Perseca O; National Institute of Public Health, 050463 Bucharest, Romania., Staicu CA; National Institute of Public Health, 050463 Bucharest, Romania., Voinoiu A; National Institute of Public Health, 050463 Bucharest, Romania., Fabiánová E; Occupational Health Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia., Bérešová J; Epidemiology Health Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia., Adamčáková ZK; Health Promotion Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia., Nedela R; Health Informatics Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia., Lesňáková A; Infectology Clinic, Central Military Hospital, 03426 Ružomberok, Slovakia., Holčíková J; Occupational Medicine Clinic, University Hospital, 83105 Bratislava, Slovakia., Boffetta P; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.; Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Abedini M; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy., Ditano G; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy., Asafo SS; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy., Visci G; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy., Violante FS; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.; IRCCS, Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy., Zunarelli C; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy., Verlato G; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2022 Jul 27; Vol. 10 (8). Date of Electronic Publication: 2022 Jul 27.
DOI:	10.3390/vaccines10081193
Abstrakt:	Background: The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers. Methods: A multicentric retrospective cohort study, involving 12 European centers, was carried out within the ORCHESTRA project, collecting data up to 18 November 2021 on fully vaccinated health workers. The cumulative incidence of SARS-CoV-2 breakthrough infections was investigated with its association with occupational and social-demographic characteristics (age, sex, job title, previous SARS-CoV-2 infection, antibody titer levels, and time from the vaccination course completion). Results: Among 64,172 health workers from 12 European health centers, 797 breakthrough infections were observed (cumulative incidence of 1.2%). The primary analysis using individual data on 8 out of 12 centers showed that age and previous infection significantly modified breakthrough infection rates. In the meta-analysis of aggregated data from all centers, previous SARS-CoV-2 infection and the standardized antibody titer were inversely related to the risk of breakthrough infection ( p = 0.008 and p = 0.007, respectively). Conclusion: The inverse correlation of antibody titer with the risk of breakthrough infection supports the evidence that vaccination plays a primary role in infection prevention, especially in health workers. Cellular immunity, previous clinical conditions, and vaccination timing should be further investigated.
Databáze:	MEDLINE
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