Vitamin D and Male Reproduction: Updated Evidence Based on Literature Review.

Autor:	Calagna G; Obstetrics and Gynecology, 'Villa Sofia Cervello' Hospital, IVF Unit, University of Palermo, Via Trabucco 180, 90145 Palermo, Italy., Catinella V; Obstetrics and Gynecology, 'Fondazione per gli Studi sulla Riproduzione Umana'-Clinica Candela, Via Valerio Villareale 54, 90141 Palermo, Italy., Polito S; Obstetrics and Gynecology, 'Villa Sofia Cervello' Hospital, IVF Unit, University of Palermo, Via Trabucco 180, 90145 Palermo, Italy., Schiattarella A; Department of Woman, Child and General and Specialized Surgery University of Campania 'Luigi Vanvitelli', Largo Madonna delle Grazie, 1, 80138 Naples, Italy., De Franciscis P; Department of Woman, Child and General and Specialized Surgery University of Campania 'Luigi Vanvitelli', Largo Madonna delle Grazie, 1, 80138 Naples, Italy., D'Antonio F; Center for High-Risk Pregnancy and Fetal Care, Department of Obstetrics and Gynecology, University of Chieti, Via dei Vestini 31, 66100 Chieti, Italy., Calì G; Obstetrics and Gynecology, 'Fondazione per gli Studi sulla Riproduzione Umana'-Clinica Candela, Via Valerio Villareale 54, 90141 Palermo, Italy., Perino A; IVF Unit, Azienda Sanitaria Provinciale di Palermo, Via G. Cusmano 24, 90100 Palermo, Italy., Cucinella G; Obstetrics and Gynecology, 'Villa Sofia Cervello' Hospital, IVF Unit, University of Palermo, Via Trabucco 180, 90145 Palermo, Italy.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2022 Aug 10; Vol. 14 (16). Date of Electronic Publication: 2022 Aug 10.
DOI:	10.3390/nu14163278
Abstrakt:	The purpose of this study was to clarify the vitamin D (VD) effect on male infertility. Our research was conducted using the following electronic databases: MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, and Cochrane Library. Selection criteria included all published randomized controlled trials and non-randomized studies, focusing on vitamin D and male reproductive function. The results showed that the effects of VD on male reproduction has been investigated in three different topics: the molecular mechanism underlying VD effects on semen quality (SQ), the relationship between VD levels and SQ, and the effect of VD supplementation on SQ. Results supported the hypothesis of a relevant interrelation between concentrations of male VD and semen parameters, with particular reference to sperm motility; on the contrary, evidence on the effect of VD on male sex steroid hormone levels was inconclusive. The results of this review hold up the thesis that VD plays a role in male reproduction. Most of the data highlighted a positive effect on semen quality, particularly in sperm motility, both in fertile and infertile men. Additional dedicated studies are required to elucidate the still controversial aspects of this topic. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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