| Autor: |
Livingstone TL; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK.; Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK., Saha S; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK., Bernuzzi F; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK., Savva GM; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK., Troncoso-Rey P; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK., Traka MH; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK., Mills RD; Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK., Ball RY; Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK., Mithen RF; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK.; Liggins Institute, Waipapa Taumata Rau-University of Auckland, 85 Park Road, Private Bag 92019, Auckland 1142, New Zealand. |
| Abstrakt: |
Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been implicated in their protective effects. Likewise, the consumption of garlic and its sulphur-containing compounds such as alliin have been associated with a reduction in risk of prostate cancer. In this study, we tested whether consuming glucoraphanin derived from broccoli seeds and alliin derived from garlic resulted in the occurrence of these potential bioactive compounds in the prostate, which may contribute to our understanding of the putative protective effects of these dietary components. We recruited 42 men scheduled for a trans-perineal prostate biopsy into a randomised, double-blinded, 2 × 2-factorial dietary supplement four-week intervention study, and 39 completed the study. The two active interventions were supplements providing glucoraphanin from broccoli (BroccoMax®) and alliin from garlic (Kwai Heartcare®). Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for alliin and associated metabolites. Sulforaphane occurred in significantly higher levels in the prostate tissue (both within the transition and peripheral zone) of men consuming the glucoraphanin containing supplements (p < 0.0001) compared to men not consuming these supplements. However, while alliin and alliin-derived metabolites were detected within the prostate, there was no significant difference in the concentrations of these compounds in the prostate of men consuming supplements derived from garlic compared to men not consuming these supplements. |
