| Autor: |
Andrei EC; Department of Histology, Faculty of Dentistry, University of Medicine and Pharmacy, 2-4 Petru Rareș Street, 200349 Craiova, Romania., Baniță IM; Department of Histology, Faculty of Dentistry, University of Medicine and Pharmacy, 2-4 Petru Rareș Street, 200349 Craiova, Romania., Munteanu MC; Department of Oro-Maxillofacial Surgery, Faculty of Dentistry, University of Medicine and Pharmacy, 200349 Craiova, Romania., Busuioc CJ; Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania., Mateescu GO; Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania., Mălin RD; Department of Otorhinolaryngology, University of Medicine and Pharmacy, 200349 Craiova, Romania., Pisoschi CG; Department of Pharmaceutical Biochemistry, University of Medicine and Pharmacy, 200349 Craiova, Romania. |
| Abstrakt: |
Oral papilloma lesions may appear as a result of HPV infection, or not, and only special molecular methods could differentiate them. Low-risk and high-risk HPV types could induce oral HPV papillomatosis with different natural evolution, clearance and persistence mechanisms. The pathogenic mechanisms are based on the crosstalk between the oral epithelial and immune cells and this very efficient virus. HPV acts as a direct inducer in the process of transforming a benign lesion into a malignant one, the cancerization process being also debated in this paper. According to the degree of malignity, three types of papillomatous lesions can be described in the oral cavity: benign lesions, potential malign disorders and malignant lesions. The precise molecular diagnostic is important to identify the presence of various virus types and also the virus products responsible for its oncogenicity. An accurate diagnostic of oral papilloma can be established through a good knowledge of etiological and epidemiological factors, clinical examination and laboratory tests. This review intends to update the pathogenic mechanisms driving the macroscopic and histological features of oral papillomatosis having HPV infection as the main etiological factor, focusing on its interreference in the local immunity. In the absence of an accurate molecular diagnostic and knowledge of local immunological conditions, the therapeutic strategy could be difficult to decide. |
