Melatonin Regulates the Daily Levels of Plasma Amino Acids, Acylcarnitines, Biogenic Amines, Sphingomyelins, and Hexoses in a Xenograft Model of Triple Negative Breast Cancer.

Autor: Junior RP; Cancer Molecular Research Laboratory, Department of Molecular Biology, Faculty of Medicine of the São José do Rio Preto, São Paulo 15090-000, Brazil., Chuffa LGA; Department of Structural and Functional Biology, Institute of Bioscience of Botucatu, Botucatu 18618-689, Brazil., Simão VA; Department of Structural and Functional Biology, Institute of Bioscience of Botucatu, Botucatu 18618-689, Brazil., Sonehara NM; Cancer Molecular Research Laboratory, Department of Molecular Biology, Faculty of Medicine of the São José do Rio Preto, São Paulo 15090-000, Brazil., Chammas R; Center for Translational Research in Oncology, Institute of Cancer of São Paulo State, University of São Paulo, São Paulo 01246-000, Brazil., Reiter RJ; Department of Cell Systems and Anatomy, UT Health, San Antonio, TX 78229, USA., Zuccari DAPC; Cancer Molecular Research Laboratory, Department of Molecular Biology, Faculty of Medicine of the São José do Rio Preto, São Paulo 15090-000, Brazil.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 14; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 14.
DOI: 10.3390/ijms23169105
Abstrakt: Metabolic dysregulation as a reflection of specific metabolite production and its utilization is a common feature of many human neoplasms. Melatonin, an indoleamine that is highly available during darkness, has a variety of metabolic functions in solid tumors. Because plasma metabolites undergo circadian changes, we investigated the role of melatonin on the profile of amino acids (AAs), biogenic amines, carnitines, sphingolipids, and hexoses present in the plasma of mice bearing xenograft triple negative breast cancer (MDA-MB-231 cells) over 24 h. Plasma concentrations of nine AAs were reduced by melatonin, especially during the light phase, with a profile closer to that of non-breast cancer (BC) animals. With respect to acylcarnitine levels, melatonin reduced 12 out of 24 molecules in BC-bearing animals compared to their controls, especially at 06:00 h and 15:00 h. Importantly, melatonin reduced the concentrations of asymmetric dimethylarginine, carnosine, histamine, kynurenine, methionine sulfoxide, putrescine, spermidine, spermine, and symmetric dimethylarginine, which are associated with the BC metabolite sets. Melatonin also led to reduced levels of sphingomyelins and hexoses, which showed distinct daily variations over 24 h. These results highlight the role of melatonin in controlling the levels of plasma metabolites in human BC xenografts, which may impact cancer bioenergetics, in addition to emphasizing the need for a more accurate examination of its metabolomic changes at different time points.
Databáze: MEDLINE
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