SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination.

Autor: Vespa S; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Simeone P; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Catitti G; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Buca D; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., De Bellis D; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Pierdomenico L; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Pieragostino D; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Cicalini I; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Del Boccio P; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Natale L; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Owens T; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark., Khorooshi R; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark., De Laurenzi V; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Stuppia L; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Department of Psychological, Health and Territory Sciences, School of Medicine and Health Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy., Lanuti P; Department of Medicine and Aging Sciences, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology (CAST), University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 11; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 11.
DOI: 10.3390/ijms23168982
Abstrakt: Recently, the protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies. We investigated the anti-spike IgG levels and SARS-CoV-2-specific T cells in 125 donors (90 vaccinated with four different vaccine platforms, 16 individuals with a previous natural infection, and 19 not vaccinated donors who did not report previous SARS-CoV-2 infections). Our data show that anti-spike IgG titers were similar between naturally infected subjects and those vaccinated with adenoviral vector vaccines. Of note, all immunized donors produced memory CD4 + and/or CD8 + T cells. A sustained polyfunctionality of SARS-CoV-2-specific T cells in all immunized donors was also demonstrated. Altogether, our data suggest that the natural infection produces an overall response like that induced by vaccination. Therefore, this detailed immunological evaluation may be relevant for other vaccine efforts especially for the monitoring of novel vaccines effective against emerging virus variants.
Databáze: MEDLINE
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