Feasibility and Acceptability of Personalized Breast Cancer Screening (DECIDO Study): A Single-Arm Proof-of-Concept Trial.

Autor:	Laza-Vásquez C; Department of Nursing and Physiotherapy and Health Care Research Group (GRECS), IRBLleida-Institut de Recerca Biomèdica de Lleida, University of Lleida, 25198 Lleida, Spain., Martínez-Alonso M; IRBLleida-Institut de Recerca Biomèdica de Lleida, Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain., Forné-Izquierdo C; Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain.; Heorfy Consulting, 25007 Lleida, Spain., Vilaplana-Mayoral J; Department of Computing and Industrial Engineering, University of Lleida, 25001 Lleida, Spain., Cruz-Esteve I; Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain., Sánchez-López I; Proteomics and Genomics Service, University of Lleida, 25198 Lleida, Spain., Reñé-Reñé M; Department of Radiology, Arnau de Vilanova University Hospital, 25198 Lleida, Spain., Cazorla-Sánchez C; Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain., Hernández-Andreu M; Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain., Galindo-Ortego G; Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain., Llorens-Gabandé M; Breast Cancer Screening Program, Catalan Institute of Health, 25006 Lleida, Spain., Pons-Rodríguez A; Example Basic Health Area, Catalan Institute of Health, 25006 Lleida, Spain.; Health PhD Program, University of Lleida, 25198 Lleida, Spain., Rué M; IRBLleida-Institut de Recerca Biomèdica de Lleida, Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain.
Jazyk:	angličtina
Zdroj:	International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Aug 21; Vol. 19 (16). Date of Electronic Publication: 2022 Aug 21.
DOI:	10.3390/ijerph191610426
Abstrakt:	The aim of this study was to assess the acceptability and feasibility of offering risk-based breast cancer screening and its integration into regular clinical practice. A single-arm proof-of-concept trial was conducted with a sample of 387 women aged 40-50 years residing in the city of Lleida (Spain). The study intervention consisted of breast cancer risk estimation, risk communication and screening recommendations, and a follow-up. A polygenic risk score with 83 single nucleotide polymorphisms was used to update the Breast Cancer Surveillance Consortium risk model and estimate the 5-year absolute risk of breast cancer. The women expressed a positive attitude towards varying the frequency of breast screening according to individual risk and, especially, more frequently inviting women at higher-than-average risk. A lower intensity screening for women at lower risk was not as welcome, although half of the participants would accept it. Knowledge of the benefits and harms of breast screening was low, especially with regard to false positives and overdiagnosis. The women expressed a high understanding of individual risk and screening recommendations. The participants' intention to participate in risk-based screening and satisfaction at 1-year were very high.
Databáze:	MEDLINE
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