Platelet-Rich Plasma in Alopecia Areata-A Steroid-Free Treatment Modality: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Autor:	Meznerics FA; Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary., Illés K; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.; Department of Otorhinolaryngology, Head and Neck Surgery, Bajcsy-Zsilinszky Hospital, 1106 Budapest, Hungary., Dembrovszky F; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.; Institute for Translational Medicine, Medical School, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary., Fehérvári P; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.; Department of Biomathematics and Informatics, University of Veterinary Medicine, 1078 Budapest, Hungary., Kemény LV; Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Kovács KD; Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Wikonkál NM; Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Csupor D; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.; Institute for Translational Medicine, Medical School, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary., Hegyi P; Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.; Institute for Translational Medicine, Medical School, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary., Bánvölgyi A; Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2022 Jul 29; Vol. 10 (8). Date of Electronic Publication: 2022 Jul 29.
DOI:	10.3390/biomedicines10081829
Abstrakt:	Background: Alopecia areata (AA) is a chronic autoimmune condition that can lead to a serious deterioration in patients' quality of life. The first line of treatment in patchy AA is triamcinolone acetonide (TrA); however, the efficacy of the treatment varies greatly. Our aim was to investigate the therapeutic effects of platelet-rich plasma (PRP) in the treatment of AA. Method: We performed a systematic literature search in four databases. Randomized clinical trials (RCT) reporting on patients with AA treated with PRP were included, comparing PRP with TrA or a placebo. The primary outcome was the Severity of Alopecia Tool (SALT) score. Results: Our systematic search provided a total of 2747 articles. We identified four studies eligible for quantitative analysis. The pooled mean differences from the four studies did not exhibit a significant difference in the mean change in the SALT score when PRP and TrA groups were compared (MD =-2.04, CI: -4.72-0.65; I 2 = 80.4%, p = 0.14). Conclusions: PRP is a promising topical, steroid-free treatment modality in the therapy of AA. No significant difference was found between PRP and TrA treatment; however, further high-quality RCTs are needed to further assess the efficacy of PRP treatment and strengthen the quality of evidence.
Databáze:	MEDLINE
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