| Autor: |
Ambrogio F; Department of Biomedical Science and Human Oncology, Unit of Dermatology, University of Bari, 70124 Bari, Italy., Sanesi L; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy., Oranger A; Department of Emergency and Organ Transplantation, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy., Barlusconi C; Department of Biomedical Science and Human Oncology, Unit of Dermatology, University of Bari, 70124 Bari, Italy., Dicarlo M; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy., Pignataro P; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy.; Department of Emergency and Organ Transplantation, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy., Zerlotin R; Department of Emergency and Organ Transplantation, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy., Romita P; Department of Biomedical Science and Human Oncology, Unit of Dermatology, University of Bari, 70124 Bari, Italy., Favoino E; Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, 70124 Bari, Italy., Cazzato G; Department of Emergency and Organ Transplantation, Pathology Section, University of Bari, 70124 Bari, Italy., Cassano N; Dermatology and Venereology Private Practice, 76121 Barletta, Italy.; Dermatology and Venereology Private Practice, 70125 Bari, Italy., Vena GA; Dermatology and Venereology Private Practice, 76121 Barletta, Italy.; Dermatology and Venereology Private Practice, 70125 Bari, Italy., Foti C; Department of Biomedical Science and Human Oncology, Unit of Dermatology, University of Bari, 70124 Bari, Italy., Grano M; Department of Emergency and Organ Transplantation, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy. |
| Abstrakt: |
Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin levels in patients with chronic plaque psoriasis, to compare them with values in controls, and to assess whether concentration of circulating irisin correlates with the severity of psoriasis, calculated by means of Psoriasis Area and Severity Index (PASI). We enrolled 46 patients with chronic plaque psoriasis; the control group included 46 sex- and age-matched subjects without any skin or systemic diseases. Serum irisin levels were measured by competitive enzyme linked immunosorbent assay. Our results showed a non-significant increase in serum irisin concentration in psoriatic patients compared to controls. A negative non-linear correlation between PASI and irisin levels was detected in psoriatic patients. Indeed, dividing patients according to psoriasis severity, the negative association between irisin and PASI was stronger in patients with mild psoriasis than in patients with higher PASI scores. Several control variables we tested showed no significant impact on serum irisin. However, erythrocyte sedimentation rate in the normal range was associated with significantly higher irisin levels in psoriatic patients. In conclusion, although irisin levels were not significantly different between controls and psoriatic patients, irisin was found to be negatively associated with psoriasis severity, especially in subjects with low PASI scores; however, further studies are needed to clarify the role of irisin in subjects with psoriasis. |
