Nutritional therapy in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis.

Autor:	Vilar MDC; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal, Brazil., Coutinho KMD; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal, Brazil., Vale SHL; Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., Medeiros GCBS; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil.; Systematic Review and Meta-Analysis Laboratory (LabSys), Federal University of Rio Grande do Norte, Natal, Brazil., Piuvezam G; Systematic Review and Meta-Analysis Laboratory (LabSys), Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Public Health, Federal University of Rio Grande do Norte, Natal, Brazil., Leite-Lais L; Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal, Brazil lucia.leite@ufrn.br.; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., Brandao-Neto J; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Aug 25; Vol. 12 (8), pp. e064086. Date of Electronic Publication: 2022 Aug 25.
DOI:	10.1136/bmjopen-2022-064086
Abstrakt:	Introduction: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease characterised by the degeneration of motor neurons. Nutritional interventions in ALS are essential and must be based on scientific evidence to provide quality of healthcare, improve the quality of life and increase survival time. Therefore, this protocol of systematic reviews and meta-analyses aims to present a synthesis of evidence-based recommendations to support adequate nutrition therapy for patients with ALS. Methods and Analysis: The search will be performed using the following databases: PubMed, Excerpta Medica Database (Embase), Scopus, SciELO, Web of Science, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), ScienceDirect, ProQuest and Google Scholar. We will include clinical practice guidelines, treatment protocols, systematic reviews and clinical trials according to the three research questions to be answered related to nutrition therapy and interventions in patients with ALS. This protocol will be developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols. To evaluate the methodological quality of the studies, Appraisal of Guidelines, Research and Evaluation II, Cochrane Risk of Bias 2.0 and Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I) tools will be used. In addition, the Grading of Recommendations Assessment, Development and Evaluation will be used to assess the quality of evidence and the strength of the recommendations. The findings will be summarised and presented descriptively according to the Cochrane Collaboration Handbook and the standard statistical meta-analysis techniques. Ethics and Dissemination: Ethical approval and human consent are not required because this is a protocol for systematic review and only secondary data will be used. Findings will be published in a peer-reviewed journal and presented at conferences. In case of any changes in this protocol, amendments will be updated in International Prospective Register of Systematic Reviews (PROSPERO) and the modifications will be explained in the final report of this review. Prospero Registration Number: CRD42021233088. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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