Eugenol reduces serum testosterone levels and sperm viability in adult Wistar rats.

Autor: Carvalho RPR; Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brazil., Lima GDA; Instituto de Ciências Biomédicas, Programa de Pós-Graduação em Biociências Aplicadas à Saúde, Universidade Federal de Alfenas, Alfenas, Minas Gerais, Brazil. Electronic address: graziela.lima@unifal-mg.edu.br., Ribeiro FCD; Departamento de Veterinária, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil; Departamento de Biologia Estrutural, Universidade Federal do Triangulo Mineiro, Uberaba, Minas Gerais, Brazil., Ervilha LOG; Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brazil., Oliveira EL; Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brazil., Viana AGA; Departmento de Medicina Veterinária, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brazil., Machado-Neves M; Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brazil; Departmento de Medicina Veterinária, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brazil. Electronic address: mariana.mneves@ufv.br.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2022 Oct; Vol. 113, pp. 110-119. Date of Electronic Publication: 2022 Aug 23.
DOI: 10.1016/j.reprotox.2022.08.012
Abstrakt: Eugenol is the main constituent of clove extract. It is a remarkably versatile molecule incorporated as a functional ingredient in several food products and widely applied in the pharmaceutical industry. Men consume natural products enriched with eugenol for treating sexual disorders and using as aphrodisiacs. Nevertheless, there is no information about the impact of eugenol intake on the reproductive parameters of healthy males. Therefore, we provided 10, 20, and 40 mg kg -1 pure eugenol to adult Wistar rats for 60 days. Testis, epididymis, and spermatozoa were analyzed under microscopic, biochemical, and functional approaches. This phenolic compound did not alter testicular and epididymal biometry and microscopy. However, 20 and 40 mg kg -1 eugenol reduced serum testosterone levels. The highest dose altered lactate and glucose concentrations in the epididymis. All the eugenol concentrations diminished CAT activity and MDA levels in the testis and increased FRAP and CAT activity in the epididymis. Epididymal sperm from rats receiving 10, 20, and 40 mg kg -1 eugenol presented high Ca 2+ ATPase activity and low motility. In conclusion, eugenol at low and high doses negatively impacted the competence of epididymal sperm and modified oxidative parameters in male organs, with no influence on their microscopy.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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