Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link.

Autor: Ramírez V; Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain; GENYO. Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government PTS Granada - Avenida de la Ilustración, 114, 18016 Granada, Spain; 'José Mataix Verdú' Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, 18100 Granada, Spain., González-Palacios P; Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain. Electronic address: pgonzapa11@correo.ugr.es., Baca MA; Clinica MenSana, Granada, Spain., González-Domenech PJ; Department of Psychiatry, Faculty of Medicine, University of Granada, 18016 Granada, Spain., Fernández-Cabezas M; Department of Developmental and Educational Psychology, Faculty of Educational Sciences, University of Granada, 18011 Granada, Spain., Álvarez-Cubero MJ; GENYO. Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government PTS Granada - Avenida de la Ilustración, 114, 18016 Granada, Spain; Department of Biochemistry and Molecular Biology III, Faculty of Medicine, University of Granada, 18016 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, Spain., Rodrigo L; Department of Legal Medicine and Toxicology, Faculty of Medicine, University of Granada, 18016 Granada, Spain., Rivas A; Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain; 'José Mataix Verdú' Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, 18100 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, Spain.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2022 Dec 15; Vol. 852, pp. 158219. Date of Electronic Publication: 2022 Aug 22.
DOI: 10.1016/j.scitotenv.2022.158219
Abstrakt: Current evidence highlights the importance of the genetic component in obesity and neurodevelopmental disorders (attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and intellectual disability (ID)), given that these diseases have reported an elevated heritability. Additionally, environmental stressors, such as endocrine disrupting chemicals (EDCs) have been classified as obesogens, neuroendocrine disruptors, and microbiota disrupting chemicals (MDCs). For this reason, the importance of this work lies in examining two possible biological mechanistic pathways linking obesity and neurodevelopmental/behavioural disorders: EDCs - gene and EDCs - microbiota interactions. First, we summarise the shared mechanisms of action of EDCs and the common genetic profile in the bidirectional link between obesity and neurodevelopment. In relation to interaction models, evidence from the reviewed studies reveals significant interactions between pesticides/heavy metals and gene polymorphisms of detoxifying and neurotransmission systems and metal homeostasis on cognitive development, ASD and ADHD symptomatology. Nonetheless, available literature about obesity is quite limited. Importantly, EDCs have been found to induce gut microbiota changes through gut-brain-microbiota axis conferring susceptibility to obesity and neurodevelopmental disorders. In view of the lack of studies assessing the impact of EDCs - gene interactions and EDCs - mediated dysbiosis jointly in obesity and neurodevelopment, we support considering genetics, EDCs exposure, and microbiota as interactive factors rather than individual contributors to the risk for developing obesity and neurodevelopmental disabilities at the same time.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Figures were created with Biorender.com.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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