Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.

Autor: Roddy DW; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.; Trinity College Institute of Neuroscience, Lloyd Building, Trinity College Dublin, Dublin, Ireland., Roman E; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., Nasa A; Trinity College Institute of Neuroscience, Lloyd Building, Trinity College Dublin, Dublin, Ireland., Gazzaz A; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., Zainy A; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., Burke T; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., Staines L; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., Kelleher I; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., O'Neill A; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., Clarke M; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland., O'Hanlon E; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.; Trinity College Institute of Neuroscience, Lloyd Building, Trinity College Dublin, Dublin, Ireland., Cannon M; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2022 Oct; Vol. 56 (7), pp. 5116-5131. Date of Electronic Publication: 2022 Sep 12.
DOI: 10.1111/ejn.15806
Abstrakt: Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11-.76) throughout all significant subsegments. In this prospective community-based cohort of school-age children, these findings suggest that white matter alterations in the limbic system may be more common in the general non-clinical adolescent population than previously thought. Such white matter alternations may only be uncovered using a similar more granular along-tract analysis of white matter tracts.
(© 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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