Stromal Vascular Fraction for Knee Osteoarthritis - An Update.

Autor:	Lana JFSD; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., Lana AVSD; UniMAX - Centro Universitário Max Planck, Indaiatuba - SP, Brazil., da Fonseca LF; Orthopaedic Department - Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo - SP, Brazil., Coelho MA; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., Marques GG; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., Mosaner T; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., Ribeiro LL; Instituto Médico Salus, São Paulo - SP, Brazil., Azzini GOM; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., Santos GS; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., Fonseca E; IOC - Instituto do Osso e da Cartilagem / The Bone and Cartilage Institute, Indaiatuba - SP, Brazil., de Andrade MAP; Federal University of Minas Gerais - Department of Locomotor Apparatus, Belo Horizonte - MG, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of stem cells & regenerative medicine [J Stem Cells Regen Med] 2022 Apr 05; Vol. 18 (1), pp. 11-20. Date of Electronic Publication: 2022 Apr 05 (Print Publication: 2022).
DOI:	10.46582/jsrm.1801003
Abstrakt:	Orthobiologics never cease to cause popularity within the medical science field, distinctly in regenerative medicine. Recently, adipose tissue has been an object of interest for many researchers and medical experts due to the fact that it represents a novel and potential cell source for tissue engineering and regenerative medicine purposes. Stromal vascular fraction (SVF), for instance, which is an adipose tissue-derivative, has generated optimistic results in many scenarios. Its biological potential can be harnessed and administered into injured tissues, particularly areas in which standard healing is disrupted. This is a typical feature of osteoarthritis (OA), a common degenerative joint disease which is outlined by persistent inflammation and destruction of surrounding tissues. SVF is known to carry a large amount of stem and progenitor cells, which are able to perform self-renewal, differentiation, and proliferation. Furthermore, they also secrete several cytokines and several growth factors, effectively sustaining immune modulatory effects and halting the escalated pro-inflammatory status of OA. Although SVF has shown interesting results throughout the medical community, additional research is still highly desirable in order to further elucidate its potential regarding musculoskeletal disorders, especially OA. Competing Interests: None (Copyright © Journal of Stem Cells and Regenerative Medicine.)
Databáze:	MEDLINE
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