Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa.

Autor:	Delanaye P; Department of Nephrology-Dialysis-Transplantation, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium.; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France., Vidal-Petiot E; Assistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université Paris Cité, Paris, France., Björk J; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.; Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden., Ebert N; Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany., Eriksen BO; Section of Nephrology, University Hospital of North Norway and Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsö, Norway., Dubourg L; Néphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale, Hôpital Edouard Herriot, Hospices Civils de Lyon, France., Grubb A; Department of Clinical Chemistry, Skåne University Hospital, Lund, Lund University, Sweden., Hansson M; Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital Huddinge and Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden., Littmann K; Department of Medicine, Karolinska Institute, Huddinge, Sweden., Mariat C; Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, Centre Hospitalier Universitaire de Saint-Etienne, France., Melsom T; Section of Nephrology, University Hospital of North Norway and Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsö, Norway., Schaeffner E; Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany., Sundin PO; Department of Geriatrics, School of Medical Sciences, Örebro University, Örebro, Sweden., Bökenkamp A; Department of Paediatric Nephrology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Berg UB; Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden., Åsling-Monemi K; Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden., Åkesson A; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.; Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden., Larsson A; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden., Cavalier E; Department of Clinical Chemistry, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium., Dalton RN; The Wellchild Laboratory, Evelina London Children's Hospital, London, UK., Courbebaisse M; Physiology Department, Georges Pompidou European Hospital, Assistance Publique Hôpitaux de Paris, Paris University, Paris, France., Couzi L; CNRS-UMR Immuno ConcEpT, Nephrologie - Transplantation-Dialyse, Centre Hospitalier Universitaire de Bordeaux, Université de Bordeaux, France., Gaillard F; Service de transplantation et immunologie clinique, Hôpital Edouard Herriot, Hospices civils de Lyon, Lyon, France., Garrouste C; Department of Nephrology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Jacquemont L; Renal Transplantation Department, Centre Hospitalier Universitaire Nantes, Nantes University, Nantes, France., Kamar N; Department of Nephrology, Dialysis and Organ Transplantation, Centre Hospitalier Universitaire Rangueil, University Paul Sabatier, Toulouse, France., Legendre C; Hôpital Necker, Assistance Publique Hôpitaux de Paris, Paris University, France., Rostaing L; Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, Hôpital Michallon, Centre Hospitalier Universitaire Grenoble-Alpes, France., Stehlé T; Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, Créteil, France.; Service de Néphrologie et Transplantation, Fédération Hospitalo-Universitaire 'Innovative therapy for immune disorders' Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Créteil, France., Haymann JP; Physiology Department, Assistance Publique- Hôpitaux de Paris, Hôpital Tenon, Paris, France., Selistre LDS; Ciências da Saúde, Universidade de Caxias do Sul, Hospital Geral de Caxias do Sul, Caxias do Sul, Brazil., Strogoff-de-Matos JP; Nephrology Division, Department of Medicine, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil., Bukabau JB; Renal Unit, Department of Internal Medicine, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Sumaili EK; Renal Unit, Department of Internal Medicine, Kinshasa University Hospital, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Yayo E; Département de Biochimie, UFR Sciences Pharmaceutiques et Biologiques, Université Felix Houphouët Boigny, Abidjan, Côte d'Ivoire., Monnet D; Département de Biochimie, UFR Sciences Pharmaceutiques et Biologiques, Université Felix Houphouët Boigny, Abidjan, Côte d'Ivoire., Nyman U; Department of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden., Pottel H; Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium., Flamant M; Cordeliers Research Center, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, and Université Paris Cité, Paris, France.
Jazyk:	angličtina
Zdroj:	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2023 Jan 23; Vol. 38 (1), pp. 106-118.
DOI:	10.1093/ndt/gfac241
Abstrakt:	Background: A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts. Methods: Standardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France (n = 4429, including 964 Black Europeans), from Brazil (n = 100) and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed. Results: In White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of -0.6 and -3.2, respectively versus 5.0 mL/min/1.73 m², and accuracy within 30% of 86.9 and 87.4, respectively, versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value (= concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males. Conclusion: In a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated population-specific Q-values, presents the best performance in the whole age range in the European and African populations included in this study. (© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.)
Databáze:	MEDLINE
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