Sleep architecture modifications after double chronotherapy: A case series of bipolar depressed inpatients.

Autor: Sarzetto A; School of Medicine, Università Vita-Salute San Raffaele, Via Stamira d'Ancona 20, Milan 20127, Italy; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy. Electronic address: alessandro.sarzetto@gmail.com., Cavallini MC; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy., Fregna L; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy., Pacchioni F; School of Medicine, Università Vita-Salute San Raffaele, Via Stamira d'Ancona 20, Milan 20127, Italy; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy., Attanasio F; School of Medicine, Università Vita-Salute San Raffaele, Via Stamira d'Ancona 20, Milan 20127, Italy; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy., Barbini B; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy., Franchini L; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy., Colombo C; School of Medicine, Università Vita-Salute San Raffaele, Via Stamira d'Ancona 20, Milan 20127, Italy; Mood Disorders Unit, IRCCS San Raffaele Scientific Institute, Via Stamira d'Ancona 20, Milan 20127, Italy.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2022 Oct; Vol. 316, pp. 114781. Date of Electronic Publication: 2022 Aug 10.
DOI: 10.1016/j.psychres.2022.114781
Abstrakt: The aim of this study is to objectively evaluate sleep architecture changes of depressed bipolar subjects treated with chronoterapeutics. Eleven depressed bipolar inpatients received 3 cycles of Total Sleep Deprivation, followed by daily light therapy sessions for one week. Polysomnography was performed before and after the treatment. Depressive symptoms significantly reduced, and sleep architecture changed with significant differences in N2% and N3% and REM density. Change in N3% was also positively correlated to depressive symptoms reduction. Although, previous studies reported sleep architecture changes after chronoterapeutics in unipolar depression, this is the first study to demonstrate changes also in bipolar depressed subjects.
Competing Interests: Declaration of Competing Interest The authors report no conflict of interests.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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