| Autor: |
Datki Z; Micro-In Vivo Research Laboratory, Interdisciplinary Research, Development and Innovation Centre of Excellence, University of Szeged, Hungary., Sinka R; Department of Genetics, Faculty of Science and Informatics, University of Szeged, Hungary. |
| Jazyk: |
angličtina |
| Zdroj: |
Advances in clinical and experimental medicine : official organ Wroclaw Medical University [Adv Clin Exp Med] 2022 Sep; Vol. 31 (9), pp. 931-935. |
| DOI: |
10.17219/acem/152430 |
| Abstrakt: |
There are numerous surprising discoveries in current comprehensive biopolymer research, including the description of new types of biopolymers and the extension of their applications. The discovery of a new rotifer-specific biopolymer family (Rotimers) and the exceptional ability of these micrometazoans to inactivate and catabolize human-type neurotoxic aggregates (e.g., beta-amyloids, alpha-synucleins, prions) by their exudates can be mentioned as the original work of our research group. Rotimers are exogenous and protein complex molecules with a calcium-dependent production mechanism in both bdelloid and monogonant rotifers. However, their experimental and application possibilities are still unknown; only part of the class has been explored and described. Current Rotimer-related studies present promising biodiversity and bioactivity of these biomaterials (e.g., antiand disaggregation effects or high degrees of adhesion to other molecules). The primary objective of current research is to explore and develop their application in translational biomedicine. A key area is the design of drug candidates against neurodegeneration-related aggregates based on the molecular information provided by the composition, structure and function of Rotimers. These novel biomaterials have the potential to open new perspectives in the pharmaceutical industry and healthcare. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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