Recommendations for connecting molecular sequence and biodiversity research infrastructures through ELIXIR.

Autor:	Waterhouse RM; Department of Ecology and Evolution and Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Vaud, 1015, Switzerland., Adam-Blondon AF; Université Paris Saclay, Versailles, 78026, France., Agosti D; Plazi, Bern, 3007, Switzerland., Baldrian P; Institute of Microbiology of the Czech Academy of Sciences, Praha, 142 20, Czech Republic., Balech B; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Bari, 70126, Italy., Corre E; CNRS/Sorbonne Université, Station Biologique de Roscoff, Roscoff, 29680, France., Davey RP; Earlham Institute, Norwich, NR4 7UZ, UK., Lantz H; Department of Medical Biochemistry and Microbiology/NBIS, Uppsala University, Uppsala, Sweden., Pesole G; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Bari, 70126, Italy.; Department of Biosciences. Biotechnology and Biopharmaceutics, University of Bari 'A. Moro', Bari, 70126, Italy., Quast C; Life Sciences & Chemistry, Jacobs University Bremen gGmbH, Bremen, Germany., Glöckner FO; MARUM - Center for Marine Environmental Sciences, University of Bremen, Bremerhaven, 27570, Germany.; Alfred Wegener Institute, Helmholtz Center for Polar- and Marine Research, Bremerhaven, 27570, Germany., Raes N; NLBIF - Netherlands Biodiversity Information Facility, Naturalis Biodiversity Center, Leiden, 2300 RA, The Netherlands., Sandionigi A; University of Milan Bicocca, Milan, 20127, Italy., Santamaria M; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Bari, 70126, Italy., Addink W; DiSSCo - Distributed System of Scientific Collections, Naturalis Biodiversity Center, Leiden, 2300 RA, The Netherlands., Vohradsky J; Laboratory of Bioinformatics, Institute of Microbiology, Prague, 142 20, Czech Republic., Nunes-Jorge A; Life Sciences & Chemistry, Jacobs University Bremen gGmbH, Bremen, Germany., Willassen NP; Dept. of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway., Lanfear J; ELIXIR Hub, Wellcome Genome Campus, Cambridge, CB10 1SD, UK.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2021 Dec 03; Vol. 10. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).
DOI:	10.12688/f1000research.73825.1
Abstrakt:	Threats to global biodiversity are increasingly recognised by scientists and the public as a critical challenge. Molecular sequencing technologies offer means to catalogue, explore, and monitor the richness and biogeography of life on Earth. However, exploiting their full potential requires tools that connect biodiversity infrastructures and resources. As a research infrastructure developing services and technical solutions that help integrate and coordinate life science resources across Europe, ELIXIR is a key player. To identify opportunities, highlight priorities, and aid strategic thinking, here we survey approaches by which molecular technologies help inform understanding of biodiversity. We detail example use cases to highlight how DNA sequencing is: resolving taxonomic issues; Increasing knowledge of marine biodiversity; helping understand how agriculture and biodiversity are critically linked; and playing an essential role in ecological studies. Together with examples of national biodiversity programmes, the use cases show where progress is being made but also highlight common challenges and opportunities for future enhancement of underlying technologies and services that connect molecular and wider biodiversity domains. Based on emerging themes, we propose key recommendations to guide future funding for biodiversity research: biodiversity and bioinformatic infrastructures need to collaborate closely and strategically; taxonomic efforts need to be aligned and harmonised across domains; metadata needs to be standardised and common data management approaches widely adopted; current approaches need to be scaled up dramatically to address the anticipated explosion of molecular data; bioinformatics support for biodiversity research needs to be enabled and sustained; training for end users of biodiversity research infrastructures needs to be prioritised; and community initiatives need to be proactive and focused on enabling solutions. For sequencing data to deliver their full potential they must be connected to knowledge: together, molecular sequence data collection initiatives and biodiversity research infrastructures can advance global efforts to prevent further decline of Earth's biodiversity. Competing Interests: No competing interests were disclosed. (Copyright: © 2021 Waterhouse RM et al.)
Databáze:	MEDLINE
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