The effect of interval and continuous work on markers of acute kidney injury in a hot environment.

Autor: Houck J; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA. houckj@husson.edu.; Department of Science, Husson University, Bangor, ME, USA. houckj@husson.edu., McKenna Z; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA., Fennel Z; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA., Ducharme J; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA., Wells A; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA.; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA., Mermier C; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA., Deyhle M; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA., Laitano O; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA., Specht J; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA., Amorim F; Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA.
Jazyk: angličtina
Zdroj: European journal of applied physiology [Eur J Appl Physiol] 2022 Nov; Vol. 122 (11), pp. 2437-2450. Date of Electronic Publication: 2022 Aug 23.
DOI: 10.1007/s00421-022-05030-1
Abstrakt: Purpose: To examine the effect of high-intensity interval work (HIIW) and moderate-intensity continuous work (MICW) on markers of acute kidney injury (AKI) and kidney function in a hot environment.
Methods: Nine males completed 2 h of work (2 × 60 min with 10 min passive rest) in a hot environment (40 °C and 15% relative humidity) as either HIIW [2 min at 80% peak oxygen consumption (VO 2 peak) and 3 min at 30% VO 2 peak] or MICW (matched for total work of HIIW). Blood and urine samples were collected immediately before (Pre), after (Post), 1 h (1 h Post), and 24 h after (24 h Post) the trials. Urine flow rate (UFR), creatinine clearance, insulin-like growth factor binding protein 7 (IGFBP7), urinary neutrophil gelatinase-associated lipocalin (uNGAL), and urinary kidney injury marker 1 (uKIM-1) were measured to assess kidney function and injury.
Results: Log IGFBP7 (p < 0.01), log uNGAL (p < 0.01), and log uKIM-1 (p = 0.01) all displayed a main effect for time after both HIIW and MICW. IGFBP7 (p = 0.01) and uKIM-1 (p < 0.01), corrected for Uosm, were higher after HIIW compared to MICW at Post, while IGFBP7 was also higher 1 h Post after HIIW compared to MICW (p = 0.02). UFR significantly decreasing from Pre to Post (p < 0.01) and 1 h Post (p < 0.01), but no main effect for condition (p = 0.53).
Conclusion: Both HIIW and MICW in a hot environment caused an increase in biomarkers of kidney injury (IGFBP7, KIM-1, and NGAL), but HIIW may have a greater impact on biomarkers related to AKI.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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