Targeted Isolation of Anti-inflammatory Lignans from Justicia aequilabris by Molecular Networking Approach.

Autor:	E Silva JPR; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Pereira LCO; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Abreu LS; Department of Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói 24220-008, Brazil., Lins FSV; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., de Souza TA; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., do Espírito-Santo RF; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40015, Brazil., Barros RPC; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Villarreal CF; School of Pharmacy, Federal University of Bahia, Salvador 41500-290, Brazil., de Melo JIM; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Scotti MT; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Costa VCO; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Martorano LH; Department of Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói 24220-008, Brazil., Dos Santos FM Jr; Department of Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói 24220-008, Brazil., Filho RB; Department of Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23890, Brazil., da Silva MS; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil., Tavares JF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of natural products [J Nat Prod] 2022 Sep 23; Vol. 85 (9), pp. 2184-2191. Date of Electronic Publication: 2022 Aug 23.
DOI:	10.1021/acs.jnatprod.2c00478
Abstrakt:	Herein, the isolation of secondary metabolites from the aerial parts of Justicia aequilabris guided by HPLC-MS n and molecular networking analyses is reported. Twenty-two known compounds were dereplicated. Three new lignans (aequilabrines A-C ( 1 - 3 )) and three known compounds (lariciresinol-4'- O- β-glucose ( 4 ), roseoside ( 5 ), and allantoin ( 6 )) were obtained. The anti-inflammatory activity of compounds 1 - 3 was evaluated in vitro by inhibiting the nitric oxide production (NO) and pro-inflammatory activity on the cytokine IL-1β. Compounds 2 and 3 showed significant inhibitory activity against NO production, with IC 50 values of 9.1 and 7.3 μM, respectively. The maximum inhibition of IL-1β production was 23.5% ( 1 ), 27.3% ( 2 ), and 32.5% ( 3 ).
Databáze:	MEDLINE
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