What good is maths in studies of wound healing?
| Autor: | Turley J; School of Mathematics, Fry Building, University of Bristol, Bristol BS8 1UG, UK.; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Chenchiah IV; School of Mathematics, Fry Building, University of Bristol, Bristol BS8 1UG, UK., Liverpool TB; School of Mathematics, Fry Building, University of Bristol, Bristol BS8 1UG, UK., Weavers H; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Martin P; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK. |
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| Jazyk: | angličtina |
| Zdroj: | IScience [iScience] 2022 Jul 19; Vol. 25 (8), pp. 104778. Date of Electronic Publication: 2022 Jul 19 (Print Publication: 2022). |
| DOI: | 10.1016/j.isci.2022.104778 |
| Abstrakt: | Wound healing is an aspect of normal physiology that we all take for granted until it goes wrong, such as, for example, the scarring that results from a severe burn, or those patients who suffer from debilitating chronic wounds that fail to heal. Ever since wound repair research began as a discipline, clinicians and basic scientists have collaborated to try and understand the cell and molecular mechanisms that underpin healthy repair in the hope that this will reveal clues for the therapeutic treatment of pathological healing. In recent decades mathematicians and physicists have begun to join in with this important challenge. Here we describe examples of how mathematical modeling married to biological experimentation has provided insights that biology alone could not fathom. To date, these studies have largely focused on wound re-epithelialization and inflammation, but we also discuss other components of wound healing that might be ripe for similar interdisciplinary approaches. Competing Interests: The authors declare no competing interests. (© 2022 The Author(s).) |
| Databáze: | MEDLINE |
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