Remotely controlled near-infrared-triggered photothermal treatment of brain tumours in freely behaving mice using gold nanostars.

Autor: Arami H; Department of Radiology, Molecular Imaging Program at Stanford, Stanford School of Medicine, Stanford, CA, USA. hamed.arami@asu.edu., Kananian S; Department of Electrical Engineering, Stanford University, Stanford, CA, USA., Khalifehzadeh L; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Patel CB; Department of Radiology, Molecular Imaging Program at Stanford, Stanford School of Medicine, Stanford, CA, USA.; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA., Chang E; Department of Radiology, Molecular Imaging Program at Stanford, Stanford School of Medicine, Stanford, CA, USA., Tanabe Y; Department of Electrical Engineering, Stanford University, Stanford, CA, USA.; Aeterlink, Chiyoda City, Japan.; AET, Chiyoda City, Japan., Zeng Y; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA., Madsen SJ; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA., Mandella MJ; Department of Radiology, Molecular Imaging Program at Stanford, Stanford School of Medicine, Stanford, CA, USA., Natarajan A; Department of Radiology, Molecular Imaging Program at Stanford, Stanford School of Medicine, Stanford, CA, USA., Peterson EE; Department of Comparative Medicine, Stanford School of Medicine, Stanford, CA, USA., Sinclair R; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA., Poon ASY; Department of Electrical Engineering, Stanford University, Stanford, CA, USA. adapoon@stanford.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. adapoon@stanford.edu., Gambhir SS; Department of Radiology, Molecular Imaging Program at Stanford, Stanford School of Medicine, Stanford, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Jazyk: angličtina
Zdroj: Nature nanotechnology [Nat Nanotechnol] 2022 Sep; Vol. 17 (9), pp. 1015-1022. Date of Electronic Publication: 2022 Aug 22.
DOI: 10.1038/s41565-022-01189-y
Abstrakt: Current clinical brain tumour therapy practices are based on tumour resection and post-operative chemotherapy or X-ray radiation. Resection requires technically challenging open-skull surgeries that can lead to major neurological deficits and, in some cases, death. Treatments with X-ray and chemotherapy, on the other hand, cause major side-effects such as damage to surrounding normal brain tissues and other organs. Here we report the development of an integrated nanomedicine-bioelectronics brain-machine interface that enables continuous and on-demand treatment of brain tumours, without open-skull surgery and toxicological side-effects on other organs. Near-infrared surface plasmon characteristics of our gold nanostars enabled the precise treatment of deep brain tumours in freely behaving mice. Moreover, the nanostars' surface coating enabled their selective diffusion in tumour tissues after intratumoral administration, leading to the exclusive heating of tumours for treatment. This versatile remotely controlled and wireless method allows the adjustment of nanoparticles' photothermal strength, as well as power and wavelength of the therapeutic light, to target tumours in different anatomical locations within the brain.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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