Medication adversely impacts visually-guided eye movements in Parkinson's disease.

Autor: Munoz MJ; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA. Electronic address: mirandamunoz2022@u.northwestern.edu., Reilly JL; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Pal GD; Department of Neurology, Rutgers University, New Brunswick, NJ, USA; Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, IL, USA., Verhagen Metman L; Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, IL, USA., Rivera YM; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Drane QH; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Corcos DM; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., David FJ; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA., Goelz LC; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2022 Nov; Vol. 143, pp. 145-153. Date of Electronic Publication: 2022 Aug 08.
DOI: 10.1016/j.clinph.2022.07.505
Abstrakt: Objective: We examined whether previous inconsistent findings about the effect of anti-Parkinsonian medication on visually-guided saccades (VGS) were due to the use of different paradigms, which change the timing of fixation offset and target onset, or different target eccentricities.
Methods: Thirty-three participants with Parkinson's disease (PD) completed the VGS tasks OFF and ON medication, along with 13 healthy controls. Performance on 3 paradigms (gap, step, and overlap) and 2 target eccentricities was recorded. We used mixed models to determine the effect of medication, paradigm, and target eccentricity on saccade latency, gain, and peak velocity.
Results: First, we confirmed known paradigm effects on latency, and target eccentricity effects on gain and peak velocity in participants with PD. Second, latency was positively associated with OFF medication Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor score in PD. Third, medication prolonged latency for the larger target eccentricity across the 3 paradigms, while decreasing gain and peak velocity in the step paradigm across target eccentricities.
Conclusions: Medication adversely affected and was not therapeutically beneficial for VGS. Previous inconsistencies may have resulted from chosen target eccentricity.
Significance: The negative medication effect on VGS may be clinically significant, as many activities in daily life require oculomotor control, inhibitory control, and visually-guided shifts of attention.
Competing Interests: Conflict of interest There are no conflicts of interest related to the research presented in this manuscript. Other financial disclosures from the past year are listed. JLR receives research support from Eli Lilly. GDP receives research support from NINDS and the Parkinson's Foundation and is on the advisory board/consults for Abbott and Guidepoint Consulting. LVM receives research support from NIH; receives research support, is on the advisory board of, and consults for Abbott and AbbVie; receives research support from and consults for Boston Scientific; receives research support from and is on the advisory board for Biogen; and receives research support from Medtronic, Neuroderm, and Prilenia Therapeutics.
(Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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